Fasting Lipid Profile and Disease Severity in Sepsis Patients
Journal Title: Journal of Clinical and Diagnostic Research - Year 2017, Vol 11, Issue 11
Abstract
Introduction: Sepsis is a systemic inflammatory response syndrome that has a proven or suspected microbial aetiology. Sepsis carries significant morbidity and mortality. During sepsis many changes occur in plasma lipids and lipoproteins. These changes help in fighting inflammation and contribute to host defence. Studies have shown that there is are relationship between low cholesterol and sepsis and the levels of total cholesterol and HDL decline during sepsis. Aim: To assess lipid profile abnormalities in patients with sepsis and to study the relation between fasting lipid profile and disease severity and mortality in patients with sepsis. Materials and Methods: This descriptive study was done at Government TD Medical College, Alappuzha, Kerala. The duration of study was one year. A total of 70 patients who were admitted to the medical intensive care unit who satisfied the American College of Chest Physicians/ Society of Critical Care Medicine (ACCP/SCCM) criteria for the diagnosis of sepsis were included in the study. Depending on the severity of sepsis, these patients were grouped into three groups-sepsis, severe sepsis and septic shock group. Results: Significantly lower values of HDL cholesterol and LDL cholesterol were observed in patients with severe sepsis and septic shock compared to patients with sepsis. Total cholesterol also showed lower values in patients with septic shock but this observation was statistically not significant. Triglycerides showed an inverse pattern with higher values in septic shock group. Conclusion: It is observed that low LDL cholesterol and high Triglycerides were associated with a significantly higher mortality in patients with sepsis.
Authors and Affiliations
P Sunayana, B Renymol, N R Ambili
Keywords
Related Articles
- EP ID EP366420
- DOI 10.7860/JCDR/2017/30268.10820
- Views 95
- Downloads 0
A study on Association of Antioxidant Status of Red Blood Cells with Type 2 Diabetes
ABSTRACT Introduction: Oxidative stress plays a role in the pathogenesis of type 2 Diabetes either by effecting insulin secretion or increasing resistance to insulin. Oxidative stress is dealt by the body with the help o...
Insulinoma: A Diagnostic Challenge!
ABSTRACT Insulinoma is a common tumour arising from islets of Langerhans. Patients with insulinomas present with neuroglycopenic symptoms such as repeated episodes of headache, blurred vision, diplopia and lethargy espec...
Spindle Cell Lipoma of the Arm: A Case Report with Review of Literature
ABSTRACT Spindle cell lipomas are rare benign tumours of adipocytes. They are usually found in middle aged to elderly males. There are a number of differential diagnoses for this lesion. Treatment is excision with no rec...
Intra- and Inter-operator Reproducibility Analysis of Automated Cloud-based Carotid Intima Media Thickness Ultrasound Measurement
ABSTRACT Introduction: Manual carotid intima media thickness (cIMT) measurements are tedious and prone to errors. Further, these measurements are subject to intra and inter-observer variability. Several studies affirm t...
Efficacy of Triple Antibiotic Paste, Moxifloxacin, Calcium Hydroxide And 2% Chlorhexidine Gel In Elimination of E. Faecalis: An In vitro Study
ABSTRACT Introduction: Root canal treatment is incomplete without usage of intra canal medicaments. They help in the reduction of bacterial count and its by-products, making canals clean and decreasing postoperative pain...