Intra- and Inter-operator Reproducibility Analysis of Automated Cloud-based Carotid Intima Media Thickness Ultrasound Measurement
Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 12, Issue 2
Abstract
ABSTRACT Introduction: Manual carotid intima media thickness (cIMT) measurements are tedious and prone to errors. Further, these measurements are subject to intra and inter-observer variability. Several studies affirm the requirement for an automated system for cIMT computation, but they still suffer from low reproducibility and lack standardisation towards clinical trials. The novelty of this study is to demonstrate the intra and inter-operator reproducibility for a cloud-based automated cIMT measurement system. Aim: To demonstrate the reproducibility analysis and validation of cloud-based automated cIMT measurement systems. Materials and Methods: The reproducibility analysis was performed by two operators at three separate times (six auto readings: 1a, 1b, 1c, 2a, 2b, 2c). For validation of cloud-based cIMT measurement system, we compared the automated readings against the manual readings by the expert. The expert readings were provided by two observers who manually traced the LI/MA borders at two separate times (four manual readings: 1a, 1b, 2a, 2b). Further, we also performed the variability analysis of the manual readings. Results: The mean Correlation Coefficients (CC) for six intra and nine inter-operator reproducibilities between the auto readings pairs were: 0.99 (p<0.001) and 0.96 (p<0.001), respectively. The mean CCs for two intra and four inter-observer variabilities between the manual readings pairs were 0.94 (p<0.001) and 0.95 (p<0.001), respectively. The accuracy computed between the mean of the six auto readings against each of the four manual readings were: 96.88%, 97.26%, 99.04%, and 98.95%, respectively. While keeping the threshold at 0.9 mm, the ROC using eight combinations give a mean AUC of 0.97±0.01. Conclusion: The proposed cloud-based automated cIMT measurement software system showed high reproducibility. The system can be adapted for routine or clinical (pharmaceutical) trial modes.
Authors and Affiliations
Luca Saba, Sumit K Banchhor, Tadashi Araki, Harman S Suri, Narendra D Londhe, John R Laird, Klaudija Viskovic, Jasjit S Suri
Keywords
Related Articles
- EP ID EP514676
- DOI 10.7860/JCDR/2018/34311.11217
- Views 66
- Downloads 0
Unusual Dyslipidemia in Patients with Chronic Kidney Diseases
Introduction: Chronic Kidney Disease (CKD) is a major and globally increasing health problem in the general population arising from a spectrum of diseases. Majority of the patients die even before reaching End Stage Rena...
Multiple Myeloma in a Patient with Sarcoidosis and Heavy Proteinuria: A Case Report
ABSTRACT The present case is of 44-year-old woman who was a known case of sarcoidosis revealed granulomatous inflammation without caseafication. She also reported to suffer from proteinuria about 2 g/day, which was repor...
Etidronate as A Weak Chelating Agent on Root Canal Dentin: An Update Review
Successful root canal treatment depends on proper biomechanical cleaning and shaping of root canal system followed by threedimensional obturation. Irrigation solutions and chelating agents are used during root canal trea...
Effect of Blood Transfusions on Oxidant/Antioxidants Balance in Beta Thalassaemia Major Patients
ABSTRACT Introduction: Thalassaemia is the major health problem all over India which is prevalent amongst all population groups irrespective of caste, religion and creed. Number of studies from different parts of the cou...
The Effect of Haemodialysis on Lipid Peroxidation and Lipid Atherogenic Risk Ratios as a Predictor of Cardiovascular Disease
ABSTRACT Introduction: Cardiovascular risk factors are prevalent in Haemodialysis (HD) patients. Aim: To assess the effect of HD on lipid peroxidation marker (Malondialdehyde (MDA)), lipid atherogenic ratios, and periphe...