FEATURES OF COMORBID COURSE OF RHEUMATOID ARTHRITIS AND HYPOTHYROID DISEASES
Journal Title: International scientific journal Science and Innovation - Year 2024, Vol 3, Issue 7
Abstract
According to data, frequent manifestations of goiter, hypothyroidism, chronic adrenal insufficiency and other endocrine gland pathologies were found in patients with RA. QB hormones increase the activity of metabolic processes, enhance lipogenesis, increase the absorption of glucose by fat and muscle tissue, activate gluconeogenesis and glycogenolysis. QB hormones (triiodothyronine - T3, thyroxine - T4) enhance both resorption and synthesis of bone tissue, activate the production of glycosaminoglycans and proteoglycans in connective tissue. An increase in the number of hormones leads to an acceleration of bone metabolism due to an increase in the number and activity of osteoclasts, and an increase in bone formation markers in the blood indicates an increase in osteoblastic function. Lack of QB hormones increases the activity of adenyl cyclase in synovial membranes, increases the production of hyaluronic acid by fibroblasts, which leads to the accumulation of synovial fluid in the joints and causes the clinical appearance of synovitis.
Authors and Affiliations
Sadullayeva Sh. M. , Shonazarova N. X.
Keywords
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- EP ID EP744746
- DOI 10.5281/zenodo.13144778
- Views 41
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