Features of lymphocyte phenotyping in patients with activated recurrent herpetic infection of the first/second type and reproductive system disorders
Journal Title: Міжнародний ендокринологічний журнал - Year 2017, Vol 13, Issue 1
Abstract
The aim of the study was an analysis of the features of changes in lymphocyte subpopulation according to the data of immunography in patients with a recrudescent herpetic infection and reproductive violations. Materials and methods. The peculiarities of lymphocyte phenotyping were studied in 120 patients with activated recurrent herpetic infection of the first/second type (herpes simplex virus (HSV) 1/2), among whom 63 patients were diagnosed with infertility. Results. An increase in the level of killer cells was detected: CD16+/56+ (NK-cells) — in moderately recurrent infection (1–5 relapses within one year) and CD3+/8+ (T-suppressor/killer cells) — in frequently recurrent infection (6 or more episodes during the year). Conclusions. In infertile patients with recurrent HSV 1/2 infection, there has been observed a deficit of cells with suppressive activity: CD4+CD25+CD127– (regulatory T-cells) lymphocytes and CD3+/8+ (T-suppressor/killer cells) lymphocytes.
Authors and Affiliations
T. V. Shmyga, V. Yu. Gayevska
Keywords
Related Articles
- EP ID EP176195
- DOI 10.22141/2224-0721.13.1.2017.96759
- Views 68
- Downloads 0
Possibilities of preoperative and intraoperative methods for the diagnosis of thyroid nodules
In case of thyroid nodules, it is important to determine the nature of the pathological process in a timely manner, since the algorithm for treating the patient depends on this. The main and effective method of preoperat...
Diabetes Mellitus Type 2 in the Practice of Family Physician
Over the past 10 years, the number of new cases of diabetes mellitus (DM) type 2 significantly exceeded the forecasts of experts. Uncompensated DM is a constant threat. But the results of clinical studies show that compl...
Diabetic Retinopathy: a New Approach to Drug Treatment
Diabetic retinopathy is a basic microvascular complication of diabetes and the leading cause of blindness in the adult population. A review of the literature on this pathology, a relatively new approach to medical treatm...
Evaluating the informativity and specificity of diagnostic criteria for primary screening for acromegaly
Background. The most effective method for early diagnosis of any disease, and especially such rare as acromegaly, is considered to be population screening in high-risk groups, the introduction of which in Ukraine require...
Association of VDR Gene Single Nucleotide Polymorphisms with the Level of Osteoassociated Hormones in Postmenopausal Osteoporosis
In the blood plasma of 74 postmenopausal women with osteoporosis (OP) and without it, we have determined the levels of osteoassociated hormones, macroelements, interleukins, cyclic nucleotides and activity of alkaline ph...