Features of the functional status of cardiovascular system and production of melatonin in boys with hypoandrogenism
Journal Title: Український журнал дитячої ендокринології - Year 2019, Vol 0, Issue 2
Abstract
The objective of the study was to determine the relationship between melatonin and the status of cardiovascular system in boys with hypoandrogenism. Materials and methods. In adolescents 14—18 years of age with delayed sexual development, total serum testosterone levels and the daily excretion of melatonin were examined. Depending on the level of testosterone, the following groups were formed: group 1 — 12.0—8.0 nmol/l; group 2 — 7.0—4.0 nmol/l; group 3 — < 4.0 nmol/l. We studied the functional status of cardiovascular system on the basis of heart rate and blood pressure levels and calculation of functional indices. Statistical analysis was carried out using the SPSS 17.0 software package with variation statistics using parametric and nonparametric methods. The critical level of significance for testing statistical hypotheses was taken no higher than 0.05. Results and discussion. It has been proven that the progression of androgen deficiency was accompanied by deterioration in the functional status of cardiovascular system against the background of a decrease in melatonin excretion (Pkw< 0.05). The highest rates of melatonin were inherent to boys with testosterone levels exceeded 12.0 nmol/l — 53.4 (22.8; 69.6) nmol/day. In adolescents of group 1, melatonin level was 47.2 (36.9; 68.7) nmol/day, group 2 — 43.9 (23.7; 55.2) nmol/day, group 3—36.9 (25.4; 57.1) nmol/day. Negative correlation between melatonin and heart rate (r = –0.40; p < 0.1), systolic (r = –0.32; p < 0.1) and diastolic blood pressure (r = –0.38) were found; p < 0.1). Regression and factor analyses have confirmed the effect of melatonin on functional status of cardiovascular system. Conclusions. Under conditions of increasing degree of hypoandrogenia with delayed sexual development in boys, a decrease in melatonin level occurs, which is most characteristic of persons with impaired functional status of cardiovascular system.
Authors and Affiliations
S. I. Turchina, G. V. Kosovtsova
Keywords
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- EP ID EP614155
- DOI 10.30978/UJPE2019-2-22
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