Fenticonazole in Vulvovaginal Infections: A Real-world Clinical Experience in India - Force India Study
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2018, Vol 6, Issue 1
Abstract
Introduction: In recent decade, fungal infections have escalated due to mushrooming of immunocompromised patients like elderly and other patients receiving immunosuppressants for comaleficent diseases diabetes mellitus, etc. This holds true for infections of vulvovaginal tissues as well. Skin and vulvovaginal infections can be effectively treated by azole class of antifungals such as clotrimazole and miconazole. Fenticonazole belongs to same class of antifungals, which has been extensively studied against fungi and some Gram-positive bacterial cocci. Aims and Objectives: We aimed to review etiological pattern of vulvovaginitis, drug use and/prescribing patterns using the World Health Organization - Drug Utilization indicators, and effects of fenticonazole (both beneficial and adverse). Materials and Methods: A survey was conducted through pre-validated questionnaire, designed to assess the effectiveness and safety of fenticonazole 600 mg ovule in the treatment of vulvovaginitis. Results: Among all variants of vaginitis, the most common variant was bacterial vaginosis (42.2%), followed by mixed vaginitis (33.2%), vulvovaginitis (14.9%), and trichomonas vaginitis (9.4%). Of 2037 prescriptions, 404 (19.8%) patients were prescribed single dose of fenticonazole, 1211 (59.4%) patients were given two doses, i.e., one ovule each, at day 1 and day 3 (D1/D3), and 419 (20.5%) patients were prescribed with two doses of fenticonazole on day 1 and day 7 (D1/D7). Prescribed daily dose of fenticonazole was more than defined daily dose. No serious adverse events were reported and it was well tolerated. Conclusion: Most of the prescriptions in the real-world setting were in D1/D3 group implying that vulvovaginitis needs to be treated adequately with two-dose regime, in contrast to single dose recommendation of standard guidelines.
Authors and Affiliations
Dhiraj Dhoot, Harshal Mahajan, Hanmant Barkate
Keywords
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