FLOATING DRUG DELIVERY SYSTEM: A COMPREHENSIVE REVIEW AND ITS POSSIBLE SCOPE
Journal Title: Int J of Pharm Rev& Res - Year 2014, Vol 4, Issue 3
Abstract
In our day to day life oral dosage forms are known to be superior because of its advantages. Furthermore new Oral sustained release dosage forms (SRDFs) have been developed; however, this approach has not been suitable for a variety of important drugs, characterized by a narrow absorption window in the upper part of the Gastrointestinal tract (GIT), the drug gets released in distal segments of the GIT which results in a short absorption phase that is often accompanied by lesser bioavailability. It was suggested that compounding narrow absorption window drugs with gastroretentive properties would enable an extended absorption phase of these drugs. New trends in GRDDS to increase the duration of oral dosage form in the stomach, includes floating systems, swelling and expanding system, modified shape system, high density systems and other delayed gastric emptying devices. Floating systems have bulk density lower than that of the gastric fluid and remain buoyant in stomach for prolong period. After oral administration; such a dosage form would be retained in the stomach and release the drug in a sustained manner, so that the drug could be supplied continuously to its absorption sites in the upper GIT. This mode of administration would provide the known pharmacokinetic and pharmacodynamics of SRDFs for such drugs; in this overview, types of floating system, factors affecting gastric retention, evaluation of floating system have been discussed.
Authors and Affiliations
Kanekar Akhil S1 , Patil Ashwini B1 , Kanavaje Abhijit M1 , Khade Amol B2, , Battase Anil P1
Keywords
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