FLOATING DRUG DELIVERY SYSTEM: A COMPREHENSIVE REVIEW AND ITS POSSIBLE SCOPE
Journal Title: Int J of Pharm Rev& Res - Year 2014, Vol 4, Issue 3
Abstract
In our day to day life oral dosage forms are known to be superior because of its advantages. Furthermore new Oral sustained release dosage forms (SRDFs) have been developed; however, this approach has not been suitable for a variety of important drugs, characterized by a narrow absorption window in the upper part of the Gastrointestinal tract (GIT), the drug gets released in distal segments of the GIT which results in a short absorption phase that is often accompanied by lesser bioavailability. It was suggested that compounding narrow absorption window drugs with gastroretentive properties would enable an extended absorption phase of these drugs. New trends in GRDDS to increase the duration of oral dosage form in the stomach, includes floating systems, swelling and expanding system, modified shape system, high density systems and other delayed gastric emptying devices. Floating systems have bulk density lower than that of the gastric fluid and remain buoyant in stomach for prolong period. After oral administration; such a dosage form would be retained in the stomach and release the drug in a sustained manner, so that the drug could be supplied continuously to its absorption sites in the upper GIT. This mode of administration would provide the known pharmacokinetic and pharmacodynamics of SRDFs for such drugs; in this overview, types of floating system, factors affecting gastric retention, evaluation of floating system have been discussed.
Authors and Affiliations
Kanekar Akhil S1 , Patil Ashwini B1 , Kanavaje Abhijit M1 , Khade Amol B2, , Battase Anil P1
Keywords
Related Articles
- EP ID EP90273
- DOI -
- Views 235
- Downloads 0
NATURAL PRODUCTS BOTACHEMICAL POTENTIALITY AND HEALTH PERSPECTIVES
It‟s well established that oxygen is essential for survival and energy generation in all-living organisms and ~5% of its inhaled part is converted into free radicals (either ROS or RNS) as a by-product of aerobic metabol...
FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF LOSARTAN POTASSIUM USING MELTGRANULATION TECHNIQUE
The purpose of the present study was to develop a sustained release matrix tablet of Losartan Potassium, a highly water soluble drug by employing hydrophobic Meltable binders like bees wax, stearic acid and emulsifying w...
REVIEW: BIOCHEMICAL COMPOSITION AND MEDICINAL USES OF CHROZOPHORA GENUS
Plants have been used for thousands of years to flavor and conserve food, to treat health disorders and to prevent diseases including epidemics. Species of Chrozophora genus (Euphobiaceae family) are distributed in West...
THE PHARMACOLOGICAL IMPORTANCE OF CENTAUREA CYANUS - A REVIEW
Chemical analysis of different parts of Centaurea cyanus revealed that the plant contained flavonoids, anthocyanins, phenilpropanic compounds, aromatic acids, phenolcarboxylic acids, amino acids, sugars, indole alkaloids...
NANOSUSPENSIONS TECHNOLOGY IN DRUG DELIVERY – A REVIEW
Nanosuspensions is colloidal dispersions of nanosized drug particles stabilized by surfactants. They can also be defined as a biphasic system consisting of pure drug particles dispersed in an aqueous vehicle in which the...