Abstract

Introduction We aimed to investigate the effectiveness and safety of flurbiprofen, a non−steroidal anti−in-flammatory drug with dual cyclooxygenase inhibition, and α−blocker alfuzosin, both alone and in combina-tion with each other for lower urinary tract symptoms suggestive of benign prostatic obstruction (LUTS/BPO). Material and methods Ninety patients complaining of moderate−to−severe LUTS/BPO were randomly assigned into 3 groups (30 patients each) to receive alfuzosin XL 10 mg, or flurbiprofen SR 200 mg, or com-bination of alfuzosin XL 10 mg and flurbiprofen SR 200 mg, once daily for 4 weeks. Patients were evaluated using the international prostate symptom score (IPSS) (total and IPSSstorage, IPSSempty subscores), uroflow-metry (maximum (Qmax) and average (Qave) flow rates) and postvoid residual urine (PVR) both at baseline and following the drug therapy course. Results There was no difference among the 3 groups regarding age and baseline values of prostate volume, IPSS, IPSSstorage, IPSSempty, Qmax, Qave and PVR (P >0.05). IPSS, IPSSstorage, IPSSempty, and PVR decreased significantly in all the 3 groups after drug therapies (P <0.01). However, Qmax and Qave significantly improved only in the combination group (P <0.01). Conclusions Addition of flurbiprofen increased the therapeutic effectiveness of alfuzosin by further im-proving symptoms in patients with LUTS/BPO. Combination therapy also improved urine flow compared to baseline. Monotherapy with flurbiprofen was not superior to alfuzosin.

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