FOETOMATERNAL OUTCOME OF OBSTETRIC CHOLESTASIS
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2017, Vol 4, Issue 59
Abstract
BACKGROUND Obstetric cholestasis is a disorder of liver function commonly occurring in the third trimester of pregnancy. Clinical characters of this disorder include unexplained maternal pruritus, most common site being palms and soles, altered liver functions (elevated serum transaminases) and increased fasting serum bile acids (>10 micro mol/L) in previously healthy pregnant women. The incidence is variable geographically from 0.1% to 15.6% all over the world. The aetiology of this condition is not fully understood. Its pathogenesis is related to increased sex hormone synthesis, environmental factors and genetic predisposition. Obstetric cholestasis can lead to increased foetal morbidity and mortality with regards to preterm delivery, neonatal respiratory distress syndrome, foetal distress and sudden intrauterine foetal death. Treatment of the disease focus on relieving symptoms and signs. The aim of the study is to evaluate the pregnancy and foetal outcome of pregnant women with obstetric cholestasis. MATERIALS AND METHODS A cross-sectional study was conducted in M.K.C.G. Medical College and Hospital, Berhampur from February 2015 to May 2017. Inclusion Criteria- All patients having pruritus during course of pregnancy with biochemical evidence of raised liver function tests attending antenatal clinic or labour room. Exclusion Criteria- 1) Pregnant women without pruritus; 2) Pregnant women having other liver diseases. RESULTS The incidence of obstetric cholestasis was 0.6%. Majority of cases were primigravida (72.9%). Positive family history was present in 11.4% of cases. Majority of cases (77.1%) had normal vaginal delivery. 22.9% of cases had caesarean section. Primary postpartum haemorrhage occurred in only 2.9% of cases. CONCLUSION Obstetric cholestasis can be managed by improving the circulating bile acid level, targeting the cause of pruritus and optimising the time of delivery as a result of which we can reduce adverse pregnancy outcomes.
Authors and Affiliations
Nina Mishra, Subhasis Panigrahy, Arpika Aparajita Behera
Keywords
Related Articles
- EP ID EP228144
- DOI 10.18410/jebmh/2017/705
- Views 68
- Downloads 0
RED BLOOD CELL ABNORMALITIES IN DECOMPENSATED CHRONIC LIVER DISEASE (DCLD)
BACKGROUND: Liver plays an important role in normal erythropoiesis, especially in formation and destruction of RBC’s. Chronic liver diseases are frequently associated with hematological abnormalities. Anemia of diverge e...
CORRELATION OF BODY FAT INDEX WITH INSULIN RESISTANCE ACROSS NORMAL, OVERWEIGHT AND OBESE INDIVIDUALS
INTRODUCTION: Obesity is defined as abnormal or excessive fat accumulation that may impair health. Insulin resistance (IR) is associated with obesity, metabolic syndrome (MS), type 2 diabetes mellitus (T2DM) and cardiova...
STUDY OF SERUM ELECTROLYTES IN FEMALE THYROID PATIENTS: A CASE CONTROL STUDY
INTRODUCTION: Thyroid hormone is a central regulator of body haemodynamic, thermoregulation and metabolism. The effect of thyroid hormones on lipid metabolism is well known, whereas the effect on electrolytes and mineral...
PSYCHOLOGICAL MORBIDITY IN PATIENTS WITH TINNITUS: A HOSPITAL BASED CROSS SECTIONAL STUDY
Tinnitus is not a disease but a symptom of hearing sound when no external sound is present. Studies have shown that some people, the sound causes anxiety or interferes with concentration, increased awareness of depressio...
A COMPARATIVE STUDY OF SMALL DOSE OF KETAMINE, MIDAZOLAM AND PROPOFOL AS COINDUCTION AGENT TO PROPOFOL
BACKGROUND The technique of “coinduction”, i.e. use of a small dose of sedative agent or another anaesthetic agent reduces the dose requirement as well as adverse effects of the main inducing agent. Ketamine, midazolam a...