Follicular Dendritic Cell Sarcoma Cytogenetics and pathological fndings
Journal Title: Sultan Qaboos University Medical Journal - Year 2015, Vol 15, Issue 3
Abstract
Follicular dendritic cell sarcoma (FDCS) is a rare neoplasm with a non-specifc and insidious presentation further complicated by the difcult diagnostic and therapeutic assessment. It has a low to intermediate risk of recurrence and metastasis. Unlike other soft tissue sarcomas or histiocytic and dendritic cell neoplasms, cytogenetic studies are very limited in FDCS cases. Although no specifc chromosomal marker has yet been established, complex aberrations and different ploidy types have been documented. We report the case of a 39-yearold woman with FDCS who presented to the Sultan Qaboos University Hospital in Muscat, Oman, in February 2013. Ultrastructural, immunophenotypical and histological fndings are reported. In addition, karyotypic fndings showed deletions of the chromosomes 1p, 3q, 6q, 7q, 8q and 11q. To the best of the authors’ knowledge, these have not been reported previously in this tumour. Techniques such as spectral karyotyping may help to better characterise chromosomal abnormalities in this type of tumour.
Authors and Affiliations
Achandira M. Udayakumar| Department of Genetics, College of Medicine & Health Sciences, Sultan Qaboos University, Maiya Al-Bahri| Departments of Pathology and 3Medicine, Sultan Qaboos University Hospital, Muscat, Oman, Ikram A. Burney| Departments of Pathology and 3Medicine, Sultan Qaboos University Hospital, Muscat, Oman, Ibrahim Al-Haddabi| Departments of Pathology and 3Medicine, Sultan Qaboos University Hospital, Muscat, Oman
Keywords
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