FORMULATION AND CHARACTERISATION OF MELOXICAM LOADED EMULGEL FOR TOPICAL APPLICATION
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 11
Abstract
Objective: The aim of the research work is to formulate emulgel of Meloxicam for topical application.Methods: The method used for preparation of microemulsion was water titration method with Oleic acid as oil phase, Tween 20 as surfactant and PEG 400 as co-surfactant and its concentrations were fixed based on Pseudoternary phase diagrams. The optimized emulsion formulation was incorporated into the gel matrix that is Carbopol981 NF and Carbopol 974 P NF.Results: The prepared emulsions were characterized for globule size, drug content, zeta potential and the emulgel for physical appearance, drug content, pH, viscosity, spreadability, extrudability and in vitro drug release studies. The optimized emulsion formulations E1 and F1 showed globule size of 176 nm and 128 nm respectively and the emulgel formulation M2F1 with 1.5% Carbopol 981 and optimized F1 emulsion formulation showed in vitro drug release of 89.934% at the end of 8 h. The optimized formulation showed no skin irritation when compared with standard irritant 0.8% of Formalin. The optimized formulation showed better anti-inflammatory effect when compared with marketed formulation.Conclusion: Meloxicam was proven to be a suitable candidate for formulating emulgel for topical delivery to achieve better patient compliance.Â
Authors and Affiliations
Arti Pednekar, Panchaxari Dandagi, Anand Gadad, Vinayak Mastiholimath
Keywords
Related Articles
- EP ID EP578157
- DOI -
- Views 46
- Downloads 0
EVALUATION OF IMMUNOMODULATORY ACTIVITY OF PETROLEUM ETHER EXTRACT OF SEEDS OF PITHECELLOBIUM DULCE IN WISTAR RATS
Objective: The present study was planned to assess the immunomodulatory action of petroleum ether extracts of seeds of Pithecellobium dulce (PEPD) in experimental models of immunity.Methods: Metronidazole, pyrogallol and...
EVALUATION OF ANTIBACTERIAL POTENTIAL OF SILVER NANOPARTICLES (SNPs) PRODUCED USING RHIZOME EXTRACT OF HEDYCHIUM CORONARIUM J. KOENIG
Objective: The bio-reduction of silver ions in solution into silver nanoparticles by rhizome extract of Hedychium coronarium as capping, reducing and stabilizing agent. Further, to evaluate the antibacterial activity of...
ESTABLISHMENT OF PSEUDERANTHEMUM PALATIFERUM (NEES) RADLK CALLUS CULTURE AND SCREENING OF SECONDARY METABOLITE PRODUCTION
Objective: This study aims to establish callus culture of Pseuderanthemum palatiferum and to investigate the production of secondary metabolites from callus extracts.Methods: Callus tissues were initiated using explants...
ANTIFUNGAL ACTIVITY OF LIPASE MODIFIED FLAVONOIDS FROM CITRUS LIMETTA
Objective: The aim of the present study is to bring about enzymatic modification of flavonoids from Citrus limetta in order to increase their antifungal activity.Methods: Methanolic extraction of flavonoids from citrus p...
DEVELOPMENT OF SPECTROPHOTOMETRIC METHODS FOR THE ANALYSIS OF FLORFENICOL IN BULK AND DOSAGE FORMS
Objectives: The objective of this research was to develop simple, sensitive and accurate zero ( °D), first (1D) and second (2D) order derivative spectrophotometric methods for the analysis of florfenicol in bulk and dos...