FORMULATION AND CHARACTERIZATION OF FAST DISINTEGRATING TABLET OF ACECLOFENAC BY USING SUBLIMATION METHOD
Journal Title: International Journal of Pharmaceutical Sciences and Drug Research - Year 2011, Vol 3, Issue 1
Abstract
In the present work, fast disintegrating tablets of Aceclofenac were prepared by subliming method with a view to enhance patient compliance. In this paper, two super-disintegrants, viz., crospovidone and sodium starch glycolate were used in different ratio (2-8 % w/w) with camphor (30 % w/w) as subliming agent. The prepared batches of tablets were evaluated for thickness, weigh variation, hardness, friability, drug content uniformity, wetting time, water absorption ratio, in-vitro disintegration time and in-vitro drug release. Based on disintegration time (approximately 21 second), three formulations were tested for the in-vitro drug release pattern (in pH 7.4 phosphate buffer). Among the three promising formulations, the formulation prepared by using 8% w/w of crospovidone and emerged as the overall best formulation based on the in-vitro drug release characteristics.
Authors and Affiliations
Kalpesh Gaur, Lalit K. Tyagi, M. L. Kori, C. S. Sharma, R. K. Nema
Keywords
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