FORMULATION AND CHARACTERIZATION OF METFORMIN HYDROCHLORIDE SUSTAINED RELEASE MATRIX TABLET CONTAINING CASSIA TORA MUCILAGE
Journal Title: Journal of Drug Delivery and Therapeutics - Year 2017, Vol 7, Issue 6
Abstract
All the present investigation an attempt has been made to study the formulation and evaluation of matrix tablet of Metformin HCL using natural mucilage of Cassia tora as a release retardant. The matrix tablet was formulated using different drug polymer ratio. The developed formulation of tablet was evaluated for pre-compression and post–compression method. The result of the pre-compression parameter like Bulk density, tapped density, Carr’s index and Hausner’s ratio were found to be with the limits indicating good flow properties of the granules. Swelling index reveals that with increasing mucilage concentration there is increased swelling showing 61% for F-2 at the end of 5 h whereas for F-3 it was around 89.9 % respectively. In- vitro drug release for F3 formulation was found to be 75% at the end of 10 h. With increases in mucilage concentration the drug release from the matrix tablet got retarded. In- vitro, drug release data obtained were fitted to various release model excess the possible mechanism of the drug release. The results of all these parameters are tabulated and depicted graphically in the result and discussion section. IR spectral studies revealed that the drug, polymer and excipients used were compatible. Drug release profile of all formulation was plotted in different kinetics. The calculated regression coefficients showed a higher r2 value with higuchi equation (r2= 0.958). Hence the release data of the Tablet obeyed higuchi model and release the drug diffusion.
Authors and Affiliations
Chandraprakash Dwivedi
Keywords
Related Articles
- EP ID EP296828
- DOI 10.22270/jddt.v7i6.1520
- Views 70
- Downloads 0
DEVELOPMENT AND VALIDATION OF HPLC METHOD FOR ESTIMATION OF BRIMONIDINE TARTRATE AS BULK DRUG AND IN OPHTHALMIC FORMULATION
The optimized reverse phase high performance liquid chromatographic method was developed for estimation of Brimonidine Tartrate in bulk drug and pharmaceutical dosage form. Chromatography was performed on Kromasil C 18 (...
DISSOLUTION ENHANCEMENT OF DIACEREIN USING WATER SOLUBLE CARRIER BY SOLID DISPERSION TECHNOLOGY
Diacerein is generally used in the treatment of Osteoarthritis , this drug comes under the class anthraquinone. The drug is practically insoluble in water and exhibits exceptionally slow and intrinsic dissolution rate wi...
FORMULATION OPTIMIZATION AND EVALUATION OF GASTRORETENTIVE TABLETS OF ONDANSETRON HCL
The aim of the work is to design Gastroretentive tablets of Ondansetron HCl for gastric retention by using 32 factorial designs. Floating tablets of Ondansetron HCl were prepared by direct compression method using polyme...
FORMULATION AND EVALUATION OF MEDICATED CHEWING GUM OF DOLASETRON AS AN ANTIEMETIC AGENT
An attempt has been made to formulate new chewing gum for Dolasetron. The new drug delivery system was obtained, at room temperature conventional pharmaceutical equipment. The resulting chewing gum comprises a gum core c...
INCREDIBLE TASTE MASKING OF CLARITHROMYCIN
Clarithromycin has poor acceptance by pediatric and geriatric patients due to bitter taste. Usually, in dry syrup formulations, high concentration of sugar is used for taste masking. But high consumption of sugar is rela...