FORMULATION AND CHARACTERIZATION OF TPP CROSS-LINKED CHITOSAN MICROSPHERES LOADED WITH LORNOXICAM
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2014, Vol 3, Issue 3
Abstract
In the present study, tripolyphosphate (TPP) cross-linked chitosan microspheres loaded with lornoxicam were prepared by ionic gelation technique. The effect of formulation and process variables on physicochemical properties of microspheres was investigated. FT-IR, DSC and XRD studies revealed the absence of any chemical interactions between the drug and excipients used. Scanning electron microscope images revealed that the prepared microspheres were discrete, broadly spherical with rough surface characteristics. The size of the microspheres was in the range of 615.32 ± 3.21μm to 855.14 ± 2.83μm which increased with increase in core: coat ratio; reduced when the pH of the TPP medium was changed from its original alkaline to acidic and also with increased extent of cross-linking. Percentage encapsulation efficiency was found to be within 56.33 ± 1.8 to 96.59 ± 3.62 and it was largely dependent on core: coat ratio, pH of the TPP medium and extent of cross-linking. Higher drug release was observed for the microspheres prepared at lower core: coat ratios and also for those prepared at the original pH of dispersion medium. On the other hand, more controlled drug release was observed with the microspheres containing higher polymeric levels prepared in the acidic medium. The drug release was also reduced with higher cross-linking conditions. Non-Fickian diffusion controlled drug release mechanism was observed for all the microspheres except those prepared at higher cross-linking conditions, which exhibited zero order release kinetics. Overall, formulation and process variables have significantly affected the physicochemical properties of the prepared microspheres.
Authors and Affiliations
Shrishailgouda S Patil*| Department of Pharmaceutics, N.E.T Pharmacy College, Raichur, Karnataka, India, V Ram Mohan Gupta| Department of Pharmaceutics, Pulla Reddy Institute of Pharmacy, Dommadugu, Dundigal, Hyderabad, Andhra Pradesh, India, K Srikanth Gupta| Department of Pharmaceutics, Pulla Reddy Institute of Pharmacy, Dommadugu, Dundigal, Hyderabad, Andhra Pradesh, India, H Doddayya| Department of Pharmaceutics, N.E.T Pharmacy College, Raichur, Karnataka, India
Keywords
Related Articles
- EP ID EP2527
- DOI -
- Views 392
- Downloads 20
DETERMINATION OF ACID INSOLUBLE ASH VALUES OF SOME MEDICINAL PLANTS OF GENUS SESBANIA
The seasonal variation of total ash, acid soluble ash and acid insoluble ash have been investigated leaves , wood and bark of Sesbania rostrata, Sesbania exaltata and Sesbania sesban , which are medicinally important....
ISOLATED TUBERCULOUS TENOSYNOVITIS OF THE RIGHT TIBIALIS ANTERIOR TENDON
Musculoskeletal system is responsible for 1‑5% of extra pulmonary tuberculosis (TB) involvement. Foot tendon involvement is very rare, with only a few cases having been reported so far. We report a case of a 15‑yearold f...
Nanoencapsulation system for delivery of protein and peptide-A review
Various nanopaticulate systems are used for the nanoenapsulation of proteins and peptides for improving peptide drug accumulation inside the target site. Due to less stability of proteins; they get readily degraded the...
ORGANOGELS IN DRUG DELIVERY
Organogels are semi-solid systems, in which an organic liquid phase is immobilized by a three-dimensional network composed of self assembled, intertwined gelator fibers. The apolar phase gets immobilized within spaces...
INSOMNIA WITH HOMOEOPATHY
Most people encounter sleep difficulties from time to time, often related to stress or pain. Many of these bouts get better without treatment. Unfortunately, in a significant proportion of the population, sleep problems...