Formulation and Design of Microparticulate Drug Delivery System of Lamivudine by Chitosan as Natural Polymer
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2017, Vol 5, Issue 1
Abstract
Abstract: The objective of work is to formulate Lamivudine loaded microparticle by counterion elicited aggregation methodology. Natural polymer such as chitosan was chosen as polycation and smaller molecular electrolytes like sodium citrate, sodium sulphate and sodium orthophosphate were chosen as polyanions. The resulted aggregate microparticles were subjected to surface morphology, size distribution, in-vitro unharness and drug excipient interaction study. Sodium citrate (SC), sodium sulphate (SS) and sodium tripolyphosphate (TPP) were able to kind aggregates, as chitosan forms complexes and depends on pH and pKa of medium. The share of entrapped drug was additional in SC primarily based microparticle as compared to SS. The SS and SC microparticles had average particle size of three hundred metric linear unit and 1250 µm severally. Also, the SEM study unconcealed additional rough and ridges on surface of SC particle as compared to SS. the upper correlation coefficient (r2) was found with Higuchi’s equation for all formulations and formulation SC2 had bigger r2 worth of 0.993 compared to any or all and obeyed fickian diffusion. There was no such major interaction were found throughout FTIR and DSC study. Additionally, stability study was performed and information showed no important amendment in assay worth for SC2. Furthermore change in crystalinity was observed by XRD study. The microparticles ready by above mentioned methodology had comfortable mechanical strength and were able to discharged drug for fifteen hours. Keywords: microparticle, sodium citrate, sodium sulphate, Lamivudine, Chitosan
Authors and Affiliations
Harekrishna Roy, Bhabani Shankar Nayak
Keywords
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