FORMULATION AND DEVELOPMENT OF TOPICAL NIOSOMAL GEL OF BCS CLASS - III ANTI-VIRAL DRUG FOR BETTER EFFICACY AS HERPES TREATMENT
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 3
Abstract
The objective of present research work was to formulate niosomal gel of ACV and to evaluate it for enhancements of skin permeation and skin retention characteristics. ACV niosomes were prepared by classical thin layer hydration method. The niosomal vesicles were separated by centrifugation method and further evaluated for percentage drug entrapment (PDE) and vesicle mean geometric diameter. The separated niosomal vesicles were incorporated into the Carbopol® 971 gel base. The niosomal gel was further evaluated for skin retention characteristics, in vitro diffusion study and stability studies at accelerated and non-accelerated conditions. The batch F12 was considered as optimized batch as it showed minimum geometric mean diameter of vesicles (1.23 ± 0.19 μm) and maximum PDE (58.71 ± 0.89 %). The in vitro diffusion study using human cadaver skin (HCS) showed 1.57 times higher flux as compared to conventional ACV gel. The skin retention study reveals that the percentage drug retained was 4.92 times higher as compared to conventional ACV gel. The stability studies at 2-8 °C showed PDE 94.23% after 12 weeks whereas at accelerated condition it was found to be 90.11%.
Authors and Affiliations
Kushal Modi , Pragna Shelat
Keywords
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