FORMULATION AND EVALUATION OF ACECLOFENAC FAST DISSOLVING TABLETS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 2
Abstract
The purpose of this study was to develop fast dissolving tablets of Aceclofenac using different concentration superdisintigrents.Fast dissolving tablets of Aceclofenac were prepared by wet granulation technique using sodium starch glycolate together with Polyplasdone xl-10 as superdisintegrants.The porous granules were then compressed in to tablets. These tablets were evaluated for drug content, weight variation, friability, hardness, wetting time and Dispersion time. All the formulations showed low weight variation with dispersion time less than 90 seconds and rapid in vitro dissolution. The drug content of all the formulations was within the acceptable limits. The optimized formulation showed good release profile with maximum drug being released at all time intervals. It was concluded that fast dissolving tablets with improved Aceclofenac dissolution could be prepared by wet granulation of tablet. The dispersion time and dissolution parameter (t50% andt80%) decreased with increasing the concentration of Polyplasdone xl-10.
Authors and Affiliations
Siraj Shaikh , Nazim Sayyed , Pravin Gomase , Afsar Shaikh , Majaz Quazi
Keywords
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