FORMULATION AND EVALUATION OF ACECLOFENAC FAST DISSOLVING TABLETS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 2
Abstract
The purpose of this study was to develop fast dissolving tablets of Aceclofenac using different concentration superdisintigrents.Fast dissolving tablets of Aceclofenac were prepared by wet granulation technique using sodium starch glycolate together with Polyplasdone xl-10 as superdisintegrants.The porous granules were then compressed in to tablets. These tablets were evaluated for drug content, weight variation, friability, hardness, wetting time and Dispersion time. All the formulations showed low weight variation with dispersion time less than 90 seconds and rapid in vitro dissolution. The drug content of all the formulations was within the acceptable limits. The optimized formulation showed good release profile with maximum drug being released at all time intervals. It was concluded that fast dissolving tablets with improved Aceclofenac dissolution could be prepared by wet granulation of tablet. The dispersion time and dissolution parameter (t50% andt80%) decreased with increasing the concentration of Polyplasdone xl-10.
Authors and Affiliations
Siraj Shaikh , Nazim Sayyed , Pravin Gomase , Afsar Shaikh , Majaz Quazi
Keywords
Related Articles
- EP ID EP134960
- DOI -
- Views 453
- Downloads 0
GASTRO PROTECTIVE EFFECTS OF FICUS DALHOUSIAE MIQ ROOTS ETHANOLIC EXTRACT IN INDOMETHACIN AND COLD RESTRAINT STRESS INDUCED ULCERS
The aim of the present study was to evaluate the gastro protective effects of FDREE in Indomethacin and cold restraint stress induced ulcer models. Wistar albino rats were employed in the study. The preliminary phytochem...
ANIMAL MODELS FOR HUNTINGTON’S DISEASES: A REVIEW
Huntington's disease (HD) is an inherited autosomal, progressive neurodegenerative disorder associated with involuntary abnormal movements (chorea), cognitive impairments and psychiatric disturbances. HD is caused by an...
TRANSGENIC FISH MODEL IN ENVIRONMENTAL TOXICOLOGY
A number of experiments and the use of drugs have been performed in fish. The fish may be used as model organism in various biological experiments, including environmental toxicology. Aquatic animals are being engineered...
COMPARISON OF LIQUISOLID AND INCLUSION COMPLEXATION TECHNIQUE FOR DISSOLUTION RATE ENHANCEMENT OF VALSARTAN
The objective of this study is to screening of suitable non volatile liquid vehicle for the formulation of liquisolid tablets such as propylene glycol, polyethylene glycol 400 and tween 80 by using mathematical equations...
NEW ASPECTS FOR TREATMENT OF SNAKE BITE: A REVIEW
Recommendation of the effective dose to the medical facility and all the possible condition. Much of the first aid currently carried out is ineffective and dangerous The right method will get the victim to the hospital q...