Formulation and evaluation of bio-nanoparticulated drug delivery of rivastigmine
Journal Title: World Journal of Pharmaceutical Sciences - Year 2016, Vol 4, Issue 5
Abstract
The purpose of the present study was to formulate and evaluate rivastigmine loaded bio-nanoparticles for effective treatment of Alzheimer’s disease. For the preparation of bio-nanoparticles biomaterial was isolated from fruits of Carica papaya by an economic method. The biomaterial recovered from the concentrate was subjected for various physicochemical properties like color, solubility, color changing point and chemical test. Bio-nanoparticles were prepared by modified nanoprecipitation method in different batches with variable drug/biomaterial ratio. Prepared batches were subjected for various evaluation studies like particle size, zeta potential, SEM, TEM, surface entrapment, in-vitro diffusion, DSC and stability. Particle size and zeta potential result revealed that all nanoformulation were within range of 1.808 to 995.1 with slight negative in charge. SEM and TEM study report indicate that formulations were spherical in shape with less or no aggregation. Less surface entrapment leads to better drug entrapped inside nanomatrix. Bio-nanoformulations were capable of releasing the drug in a slow sustained manner. From the present investigation, it may be concluded that biomaterial isolated from fruits of Carica papaya used in the preparation of bio-nanoparticle act as an efficient carriers for deliver rivastigmine at a controlled rate. It may serve as an effective tool to treat Alzheimer’s disease.
Authors and Affiliations
Mr. Sayantan Mukhopadhyay
Keywords
Related Articles
- EP ID EP198676
- DOI -
- Views 85
- Downloads 0
Stability indicating RP-HPLC method development and validation of metformin hydrochloride and glimepiride in bulk and pharmaceutical dosage form
A stability indicating RP-HPLC method was developed and validated for the determination of Metformin HCl and Glimepiride in tablet dosage form. The method was carried out using Agilent C18 column (250 mm×4.6 mm, 5 μ) wit...
Effect of Ocimum sanctum Linn (Tulsi) leaves on pyrexia
Background: Drug therapy of fever with Standard drugs, are always accompanied by side effects which is a well-known factor and the therapy is open to other alternative/adjuvant supplements/ medications with no/minimal si...
Synthesis of highly pure esomeprazole sodium with polymorphic form J
The present disclosure relates to a process of preparing excellent quality esomeprazole sodium, which is devoid of product related impurities. Esomeprazole sodium performed via preparation of sodium-salt using key starti...
A Review on current scenario of spirulina drug delivery systems
Spirulina is a microalga that has been consumed for centuries due to its high nutritional value and presumed health benefits. Today, attractive lifestyle personalities endorse Spirulina as a hidden, potent "superfood," a...
Measuring the Sun Protection Factor of Sunscreens
The purpose of this study was to evaluate the sun protection factor (SPF) of sunscreens marketed formulations by employing ultraviolet spectroscopic method, nine different marketed formulations were selected in this rega...