Synthesis of highly pure esomeprazole sodium with polymorphic form J
Journal Title: World Journal of Pharmaceutical Sciences - Year 2016, Vol 4, Issue 11
Abstract
The present disclosure relates to a process of preparing excellent quality esomeprazole sodium, which is devoid of product related impurities. Esomeprazole sodium performed via preparation of sodium-salt using key starting material esomeprazole potassium. Herein, reported an excellent method to get polymorph J of esomeprazole sodium using acetonitrile maceration. In this development overall yield is 70-80% with purity more than 99%.
Authors and Affiliations
Dr. Sandip Sadaphal
Keywords
Related Articles
- EP ID EP203708
- DOI -
- Views 91
- Downloads 0
Flame Emission and Molecular Absorption Spectrophotometric Determination of Promethazine Hydrochloride via Potassium Dichromate as Oxidant Reagent
Two simple, rapid and sensitive Flame Atomic Emission and Molecular Absorption Spectrophotometric method for determination of trace amount of promethazine hydrochloride in pure and its pharmaceutical preparations were de...
A review on solid dispersion and latest approaches used to improve solubility of poorly water soluble drugs
In the present day solubility of drugs in GIT fluids becomes necessary for the preparation of solid unit dosage forms of drugs. Otherwise if the drug has poor solubility then the drug does not show its effect properly in...
Acute and subchronic oral toxicity assessment of leaves aqueous extract of Triumfetta pentandra (Tiliaceae) on mice and rats
Triumfetta pentandra is used in African traditional medicine against diabetes mellitus, goiter and wounds. The objective of the study was to evaluate the acute and subchronic oral toxicity of leaves aqueous extract of T....
First prescription analysis of anxiolytics in a tertiary care center: a pilot study
Background: There is limited evidence in Indian literature regarding the prescribing pattern of anxiolytics. Hence a drug utilization study was designed to assess the prescription trends of antxiolytics in our tertiary c...
A Study on abdominal pain with patients suffering with dengue fever with surgical presentations
To ascertain different etiologies for abdominal pain in dengue fever with their respective incidence and their management. Patients admitted with dengue fever (confirmed by ELISA or NS1Ag) with pain abdomen in our hospit...