Synthesis of highly pure esomeprazole sodium with polymorphic form J
Journal Title: World Journal of Pharmaceutical Sciences - Year 2016, Vol 4, Issue 11
Abstract
The present disclosure relates to a process of preparing excellent quality esomeprazole sodium, which is devoid of product related impurities. Esomeprazole sodium performed via preparation of sodium-salt using key starting material esomeprazole potassium. Herein, reported an excellent method to get polymorph J of esomeprazole sodium using acetonitrile maceration. In this development overall yield is 70-80% with purity more than 99%.
Authors and Affiliations
Dr. Sandip Sadaphal
Keywords
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