FORMULATION AND EVALUATION OF CANDESARTAN CILEXETIL IMMEDIATE RELEASE TABLETS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 7
Abstract
Candesartan Cilexetil is an esterified prodrug of Candesartan, a non-peptide angiotensin II type-1(AT1) receptor antagonist used in the treatment of hypertension and congestive heart failure. Candesartan meets the requirement of high potency but it is poorly absorbed when administered orally. Therefore, the prodrug Candesartan Cilexetil is developed. It is soluble in methylene chloride, half life is 5.1 to 10.5hrs and bioavailability is 15%. It is marketed as conventional tablets. In this work, it is formulated as immediate release tablets by changing the concentration of ingredients. For many drug substances, conventional immediate-release formulations provide clinically effective therapy while maintaining the required balance of pharmacokinetic and pharmacodynamic profiles with in acceptable level of safety to the patient. The immediate release formulation of Candesartan Cilexetil is prepared by wet granulation method to provide rapid onset of action. In order to optimize the best formulation, ten different trials are developed. The main ingredients used in the formulation are lactose monohydrate, PEG, calcium CMC and MCC. Weight variation, thickness, friability, disintegration time, in-vitro release, pharmaceutical assay are studied as response variables. The formulation containing 38% of MCC is selected as an optimized product in which the different physical properties and in-vitro release profile showed best comparable results with innovator product.
Authors and Affiliations
Neeharika Jampani , Ravi Bonthu , Mamatha Reddy
Keywords
Related Articles
- EP ID EP86883
- DOI -
- Views 99
- Downloads 0
EFFECT OF NON IONIC SURFACTANT ON THE SOLUBILITY AND DISSOLUTION OF SIMVASTATIN
Various investigators have been facing the problems in improving solubility, dissolution and bioavailability of poorly water soluble drugs. Solid dispersion is a unique approach to improve the solubility of poorly water...
SIMULTANEOUS ESTIMATION AND VALIDATION OF VARDENAFIL AND DAPOXETINE HYDROCHLORIDE IN PHARMACEUTICAL FORMULATION BY THIN LAYER CHROMATOGRAPHIC DENSITOMETRIC METHOD
The present manuscript describes new, simple, accurate, and precise high performance thin layer chromatography method for the simultaneous determination of Vardenafil and Dapoxetine in combined tablet dosage form. Chroma...
ETHNOBOTANICAL UTILIZATION OF SOME MEDICINAL PLANTS BY BODO PEOPLE OF MANAS BIOSPHERE RESERVE IN THE TREATMENT OF MALARIA
Malaria is a parasitic disease caused by Plasmodium falciparum and P. vivax, transmitted by a female Anopheles mosquito from the blood of an infected person to a healthy person. Malaria is one of the major problem in No...
OPTIMIZATION OF MICROWAVE ASSISTED EXTRACTION OF PHENOLIC COMPOUNDS FROM DECALEPIS HAMILTONII ROOT USING RESPONSE SURFACE METHODOLOGY
Polyphenolic compounds comprising flavonoids and phenolic acids are widely distributed in foods of plant origin and counted to be the most abundant antioxidant in our diet. Due to its health benefitting properties they a...
FORMULATION AND EVALUATION OF DENTAL FILM FOR PERIODONTITIS
Controlled release local drug delivery systems offer advantages compared to systemic dosage forms for periodontitis. The objective of this research was to design and evaluate sustained release dental films containing lom...