Formulation and evaluation of clozapine solidlipidnanoparticles with natural lipid
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2014, Vol 2, Issue 12
Abstract
Solid lipid nanoparticles of poorly soluble drug (Clozapine) were prepared by using different lipids (Ghee, BBS-C, Dynasan118) with different surfactants (Acconon MC8 EP/NF, Gelucire 44/14, Labrasol, Tween 80, Capmul MCM) in the ratio 1:1. Clozapine SLNs were prepared by hot homogenization technique followed by ultrasonication and its particle size, zeta potential, morphology, entrapment efficiency and drug release in vitro were studied. The FT-IR and DSC studies of prepared formulations revealed that the drug was existed in amorphous state. SEM studies revealed that Clozapine loaded SLNs were almost spherical in shape with particle size range of below 50nm.
Authors and Affiliations
G. Y. Srawan Kumar| Department of Pharmaceutics, Hindu College of Pharmacy, Amaravathi Road, Guntur- 522002, (A.P.) India., K. Madhuri*| Department of Pharmaceutics, Hindu College of Pharmacy, Amaravathi Road, Guntur- 522002, (A.P.) India.
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