Formulation and Evaluation of Colon Targeted pH Dependent Microcapsules of Thymoquinone for Colorectal Cancer
Journal Title: Saudi Journal of Medical and Pharmaceutical Sciences - Year 2017, Vol 3, Issue 11
Abstract
Abstract:Aim of the present work was to prepare the colon-targeting pH dependent microcapsules of Thymoquinone for the treatment of colorectal cancer. pH dependent polymer Eudragit L100,and S100 were used to formulate the microcapsules by solvent evaporation technique using two methods. Microcapsules were evaluated for particle size, shape, flow properties, surface morphology by scanning electron microscopy, percentage yield, drug content, and in vitro drug release behaviour, in vivo targeting efficiency. The formulated microcapsules were discrete, almost spherical with somewhat folded and invaginated surface, and with good flow properties. Thymoquinone loaded microcapsules demonstrated good entrapment efficiency (of 86.438% in method 1 and 92.49% in method 2). Result of in vivo targeting efficiency showed that the formulation can able to target colon effectively. Formulation done by method 2 gave most promising result compared to first method. It is concluded from the present study that pH dependent Eudragit microcapsules are promising carriers for oral colon-targeted delivery of Thymoquinone for colorectal cancer. Keywords:Thymoquinone, Eudragit L-100, Eudragit S-100, microcapsules, pH dependent, colon targeting, colorectal cancer
Authors and Affiliations
Afsana Nazeer, Neema George
Keywords
Related Articles
- EP ID EP393600
- DOI -
- Views 78
- Downloads 0
Morphometry and Indices of Tibia and Their Importance
The tibia is the strong weight bearing bone of the leg. It has usually a single nutrient foramen. Of late, tibia is gaining importance in determining the stature, sex and race of individuals and in the identification of...
Separation and Quantitation of Rapamycin, Termsirolimus Regio Isomer (Monoester) and Termsirolimus Diester in Termsirolimus by Normal Phase HPLC
Normal-Phase High Performance Liquid Chromatography method was developed for determination of Rapamycin, Temsirolimus Regio isomer (monoester) and Temsirolimus diester in Temsirolimus drug and pharmaceutical formulations...
CymbopogoncitratusStapf(DC) extracts alleviate gasoline vapour-induced metabolic disorders and cardiovascular disease risk in rats
Abstract: Alternative therapies for the alleviation of chemical/xenobiotic-induced metabolic aberrations and risk factors for cardiovascular disease have been inadequately explored, despite their rich cardiovascula...
Mineral Content and Chemical Composition of Napier (Pennisetumpurpureum) Grass
Abstract:Napier grass is a popular tropical grass, employed by farmers in livestock nutrition. In this work, the matrices of matured shoots of P. purpureum (schumach) commonly called Napier grass, were subjected to pr...
Quantification of Two Bleaching Agents: Hydroquinone and Clobetasol-17 Propionate in Lightening Creams and Body Milks Marketed in the City of Douala (Cameroun)
Hydroquinone (HQ) and clobetasol 17-propionate (17PC) are two medicinal agents commonly incorporated because of their skin bleaching properties into lightening cosmetics sold out in some sub-Saharan regions (Senegal, To...