Abstract

The present study deals with the investigation carried out on developing a fast dissolving delivery system releasing Domperidone concomitantly in stomach for treating vomiting and motion sickness. Domperidone FDOF was prepared by solvent casting principle. Different concentration of film forming polymer i.e. Domperidone with and without solubilising agent tween 80 was used to formulate FD of Domperidone. The films formulated by incorporating a solubilising agent i.e. tween 80 had better. Korsmeyerpeppas model was found to be best fit kinetic in which all formulation showed good linearity (R2: 0.906 to 0.989), with slope (n) values ranging from 0.655 to 0.981.In Korsmeyer-Peppas model, ‘n’ is the release exponent indicative of mechanism of drug release. The ‘n’ values ranged from 0.5-1.0 indicate Anomalous transport (non-fickian) diffusion where drug release is both diffusion and swelling controlled.

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