FORMULATION AND EVALUATION OF EFFERVESCENT TABLETS OF ACECLOFENAC
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 12
Abstract
Recently, fast-dissolving drug delivery systems have started gaining popularity and acceptance as new drug delivery systems, because they are easy to administer and lead to better patient compliance. Usually, elderly people experience difficulty in swallowing the tablet. Aceclofenac is a NSAID which has greater inhibitory action against the inducible form of cyclooxygenase (COX-2) which is implicated in the inflammatory response against the constitutive form of this enzyme (COX-1) inhibition. The aim of this study was to formulate Effervescent tablet with sufficient mechanical integrity and to achieve faster disintegration in the water. Effervescent tablets are uncoated tablets that generally contain acid substances and carbonates or bicarbonates and which react rapidly in the presence of water by releasing carbon dioxide. They are intended to be dissolved or dispersed in water before use. Effervescent compositions in the form of tablets comprising a therapeutic agent, a granulating agent, a micro particulate effervescent component and an effervescent system which dissolve rapidly in water to yield an effervescent solution containing a completely dissolved therapeutic agent and a process for their preparation.
Authors and Affiliations
P Palanisamy , Abhishekh Rabi , Yoganand Kumar
Keywords
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