FORMULATION AND EVALUATION OF ENTERIC COATED TABLETS OF PROTON PUMP INHIBITOR
Journal Title: Journal of Basic and Clinical Pharmacy - Year 2010, Vol 1, Issue 4
Abstract
The present study was an attempt to formulate and evaluate enteric coated tablets for esomeprazole magnesium trihydrate. Different core tablets were prepared and formulation (F-1) was selected for further enteric coating, based on the disintegration time. Seal coating was applied to achieve 3% weight gain using opadry®. Enteric coating was carried out using different polymers like Eudragit L-30 D-55, hydroxy propyl methylcellulose phthalate, cellulose acetate phthalate and Acryl-EZE® to achieve 5% weight gain. Disintegration studies showed that the formulations failed in 0.1 N HCl media. Hence the quantity of enteric coating was increased to 8% w/w. In vitro analysis of the developed tablets was carried out. Results from disintegration time and dissolution rate studies indicate that all the esomeprazole enteric tablets prepared possess good integrity, desirable for enteric coated tablets. Among the polymers studied,the methacrylic polymers exhibited better dissolution rate than the cellulose polymers.Stability studies indicate that the prepared formulations were stable for a period of three months. This study concluded that enteric coated tablets of esomeprazole can be prepared using any of the enteric coating polymer studied using a minimal weight gain of 8%.
Authors and Affiliations
Anroop Nair, Rachna Kumria, Rachna Gupta, Shery Jacob, Mahesh Attimarad
Keywords
Related Articles
- EP ID EP135003
- DOI -
- Views 79
- Downloads 0
AN OVERVIEW OF NUTRACEUTICALS: CURRENT SCENARIO
Using food products to promote health and cure disease is renowned.Currently, most of the drug molecules available in the formulations were ancientlyused in their crude form. Dr Stephen De Felice first coins the te...
A COMPARATIVE EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF THE BARK OF FICUS BENGALENSIS IN PLANTS OF DIFFERENT AGE
The medicinal plants have been selected for thorough studies from indigenous folk medicines, Ayurvedic, Unani and Siddha systems of medicines. The aim of this study deals with the comparative evaluation of anti-inflammat...
Antibacterial and Cytotoxic Activity of Ethanol Extract of Mikania Cordata (Burm.F.) B.L. Robinson Leaves
The purpose of the present study to examine the antibacterial and cytotoxic properties of ethanol extract of leaves of Mikania cordata (Burm.f.) B.L. Robinson. To determine antibacterial activities, the extract was teste...
Anti-Infl ammatory Activity of Aqueous Extract of Beta Vulgaris L.
The present study deals with the investigation of phytochemically evaluated aqueous extract of leaves of Beta vulgaris for its anti-inflammatory activity. The anti-inflammatory activity was evaluated by carrageenan induc...
Thrombolytic potential of Ocimum sanctum L., Curcuma longa L., Azadirachta indica L. and Anacardium occidentale L.
Atherothrombotic diseases such as myocardial or cerebral infarction are serious consequences of the thrombus formed in blood vessels. Thrombolytic agents are used to dissolve the already formed clots in the blood vessels...