FORMULATION AND EVALUATION OF ETODOLAC NIOSOMES BY MODIFIED ETHER INJECTION TECHNIQUE
Journal Title: UNKNOWN - Year 2016, Vol 1, Issue 1
Abstract
Etodolac is an indole acetic acid derivative with half-life of 4 to 7 hrs. It is used for the treatment of Rheumatoid arthritis. Whenever used orally, it has many systemic side effects, so it is not preferred orally. In present study four niosomes formulations of Etodolac were successfully developed by modified ether injection technique using different nonionic surfactant i.e. Span 20, Span 40, Tween 20, Tween 40 and cholesterol. Formulations were evaluated for different parameters like particle size, entrapment efficiency, in-vitro release, stability studies. Keywords: Etodolac, niosomes, surfactants, cholesterol, modified ether injection method, in-vitro release, stability studies
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