FORMULATION AND EVALUATION OF FAST DISSOLVING BUCCAL FILM OF ENALAPRIL MALEATE
Journal Title: Journal of Pharmaceutical and Scientific Innovation - Year 2017, Vol 6, Issue 6
Abstract
In the development of buccal drug delivery system, mucoadhesion i.e.; the binding to mucin layer of biological membrane is the key element. Buccal film delivery system consist of at thin film, which is simply placed on the patient’s tongue or mucosal tissue, instantly wet by saliva; the film rapidly dissolves, then it rapidly disintegrates and dissolves to release the medication for oral mucosal absorption. Here 5 Formulations of Enalapril Maleate oral films were formulated and produced by using solvent casting technique using the polymer hydroxyl propyl methyl cellulose based on various polymer excipients ratio and were evaluated. The infrared spectra showed stable and compatible character of the drug with the excipients and polymer. The F1 formulation was found to be the best formulation. The Formulation 1 with HPMC 250mg showed optimum swelling properties, maximum drug release and residence time.
Authors and Affiliations
Irene Thomas, Binu Anand, Beena P, Elessy Abraham
Keywords
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- EP ID EP453314
- DOI 10.7897/2277-4572.06667
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