FORMULATION AND EVALUATION OF FAST DISSOLVING NIMESULIDE TABLETS BY SOLID DISPERSION TECHNIQUE 

Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 4

Abstract

The aim of this study was to prepare fast dissolving tablets of Nimesulide by employing solid dispersion technique. Formulations were evaluated for precompressional parameters such as angle of repose, % compressibility and hausner’s ratio. Tablets were subjected to post compressional analysis for the parameters such as hardness, friability, in- vitro disintegration time, wetting time and dissolution. Stability studies were carried out as per ICH guidelines for three months. The results revealed that tablets prepared by solid dispersion having drug to PVP ratio of 1:3 (P3), yielded the best result in terms of dissolution rate. Stability studies revealed that upon storage tablets prepared by solid dispersion with PVP did not show any change in disintegration time after stability studies.  

Authors and Affiliations

Chandrashekhar Patil , Basawaraj Patil , Srinivas Soodam , Amaregouda , Rajesh B. R. C.

Keywords

Related Articles

ANTIMICROBIAL CONSTITUENTS FROM PLANTS 

Research on medicinal plants showed promising constituents for effective treatment and management of various illnesses. Microbes are commonly found everywhere which causes many diseases to the man kind. Antibiotics avail...

SIMULTANEOUS ESTIMATION AND VALIDATION OF PARACETAMOL, CHLORPHENIRAMINE MALEATE AND PHENYLEPHRINE HYDROCHLORIDE IN BULK AND TABLET DOSAGE FORM BY USING DIFFERENT SPECTROPHOTOMETRIC METHOD  

A simple, precise, accurate and economic simultaneous UV spectrophotometric method has been developed for the estimation of Paracetamol, Chlorpheniramine Maleate and Phenylephrine Hydrochloride in combination in bulk mix...

GOLDEN BENEFITS OF DRINKING KOKAM-COLA 

Kokam fruit can be viewed as a wonder berry that has a pleasant, tangy-sweet taste and a myriad of health benefits. This exotic fruit is a native of Sahyadri Mountain range of Western India. Kokam (Garcinia indica), grow...

THE ROLES OF CLINICAL PHARMACY IN REDUCING MEDICATION ERRORS 

Potential activation of clinical pharmacist role is of great importance in reducing the medication errors which are a well- known problem in hospital. The medication errors could be prescribing errors, dispensing errors,...

FIXED DOSE COMBINATION AND DISEASE MANAGEMENT 

Fixed dose combinations (FDCs) are combinations of two or more active drugs in a single dosage form. It is the current hot topic of deliberations in the pharmaceutical industry, drug regulatory agency, and the pharmaceut...

Download PDF file
  • EP ID EP114049
  • DOI -
  • Views 114
  • Downloads 0

How To Cite

Chandrashekhar Patil, Basawaraj Patil, Srinivas Soodam, Amaregouda, Rajesh B. R. C. (2011). FORMULATION AND EVALUATION OF FAST DISSOLVING NIMESULIDE TABLETS BY SOLID DISPERSION TECHNIQUE . International Research Journal of Pharmacy (IRJP), 2(4), 145-148. https://europub.co.uk/articles/-A-114049