FORMULATION AND EVALUATION OF FAST DISSOLVING NIMESULIDE TABLETS BY SOLID DISPERSION TECHNIQUE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 4
Abstract
The aim of this study was to prepare fast dissolving tablets of Nimesulide by employing solid dispersion technique. Formulations were evaluated for precompressional parameters such as angle of repose, % compressibility and hausner’s ratio. Tablets were subjected to post compressional analysis for the parameters such as hardness, friability, in- vitro disintegration time, wetting time and dissolution. Stability studies were carried out as per ICH guidelines for three months. The results revealed that tablets prepared by solid dispersion having drug to PVP ratio of 1:3 (P3), yielded the best result in terms of dissolution rate. Stability studies revealed that upon storage tablets prepared by solid dispersion with PVP did not show any change in disintegration time after stability studies.
Authors and Affiliations
Chandrashekhar Patil , Basawaraj Patil , Srinivas Soodam , Amaregouda , Rajesh B. R. C.
Keywords
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