FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF OFLOXACIN BY DIRECT COMPRESSION METHOD
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2013, Vol 4, Issue 11
Abstract
Ofloxacin is a broad-spectrum, synthetic fluoroquinolones antibacterial agent for oral administration. The bioavailability of ofloxacin in the tablet formulation is approximately 98 %. It is extremely bitter in taste, water insoluble drug. It is used to treat variety of infections. The purpose of the present research work was to formulate and evaluate the fast dissolving tablets of ofloxacin by direct compression method using different super disintegrants like PGS (pre gelatinized starch), SSG (sodium starch glycolate), PVPP (ploy vinyl poly pyrrolidone) in different concentrations 5 %, 7.5 %, 10 %. FT-IRspectroscopy was used to investigate the physical characteristics of the complex. The blend was evaluated for angle of repose, bulk density, tapped density, carr’s index, hausner ratio. The tablets were evaluated for weight variation, hardness, friability, disintegration time, water absorption ratio, wetting time, drug content uniformity and in vitro dissolution. Tablet formulated with 10 % (F9) of PVPP showed low disintegration time (8 2), wetting time (4.3 0.3), friability than the other batches. The % cumulative release of drug from tablet (F9) was found to be more than 87 % within 10 minutes. It was concluded from the study that ofloxacin may improve patient compliance especially pediatric and geriatric patients and increase the efficacy of drug for treating infections.
Authors and Affiliations
Shivaramakrishna Baddam, Sreedhar Bandari, G. B Chaithanya
Keywords
Related Articles
- EP ID EP99101
- DOI 10.7897/2230-8407.041118
- Views 130
- Downloads 0
QSAR MODELING OF BENZOXAZINE-3-ONES DERIVATIVES AGAINST CANDIDA KRUSEI
QSAR Study on the inhibition of Candida krusei by Benzoxazine-3-ones derivative using several physiochemical descriptors was performed. Antifungal activity for 16 Benzoxazine-3-ones derivatives was modeled by using multi...
ANALYTICAL STUDY OF CURCUMIN CONTENT IN DIFFERENT DOSAGE FORMS CONTAINING TURMERIC EXTRACT POWDER AND TURMERIC OLEORESIN
Different dosage forms namely tablets, capsules, creams and syrups were analysed for curcumin content, by the well-known spectrophotometric method. Turmeric extract powder was used as a source of curcumin in capsule and...
INVESTIGATION OF POSSIBLE HYPOGLYCEMIC AND HYPOLIPIDEMIC EFFECT OF METHANOLIC EXTRACT OF SESBANIA GRANDIFLORA
Sesbania grandiflora (Leguminosae: Papilionoideae), cultivate all over India, has wide range of therapeutic actions. The aim of the current study has been to investigate the possible hypoglycemic and hypolipidemic effect...
DETERMINATION OF PERMEATION PATHWAY OF GENTAMICIN INTO PIG’S EAR SKIN
Extensive research has been conducted in the recent years with a focus on drug administration via the skin for both topical and systemic drug delivery. Understanding the drug permeation through the skin is crucial for th...
DESIGN AND CHARACTERIZATION OF CLARITHROMYCIN BEADS USING A BIODEGRADABLE CATIONIC POLYMER
The objective of the present study was to prepare clarithromycin beads by ionotropic gelation method using cationic polymer. Infra red spectroscopy study showed that the drug and excipients were compatible with each othe...