Formulation and evaluation of fast dissolving tablets of simvastatin using novel co-processed superdisintegrants
Journal Title: Scholars Academic Journal of Pharmacy - Year 2013, Vol 2, Issue 4
Abstract
The aim of the present investigation was to develop fast dissolving tablets of Simvastatin, an lipid-lowering drug used for the reduction of VLDL. Due to its low solubility and its short biological half-life of 3 hours, fast dissolving tablets of Simvastatin were prepared using superdisintegrants in order to improve the dissolution rate, thereby the absorption. The influence of concentration of the Ac-Di-Sol was studied by a set of four formulations (F1, F2, F3, F4) with concentrations of Ac-Di-Sol viz, 2%, 3%, 4% & 5%w/w respectively. Also the influence of various superdisintegrants was studied by a set of three formulations (F4, F5 and F6) with three superdisintegrants viz, Ac-Di-Sol (5%), Croscarmellose sodium(5%), Crospovidone (5%) respectively. The formulation prepared with 5%w/w of Ac-Di-Sol was offered relatively rapid release of Simvastatin n when compared with other concentrations of Ac-Di-Sol. The formulation prepared with Crospovidone was offered relatively rapid release of Simvastatin when compared with other superdisintegrants. Various formulations were prepared incorporating a combination of superdisintegrants (Physical Mixtures and Co-processed Mixtures), Ac-Di-Sol and Crospovidone by direct compression method. Formulation containing Co-processed mixtures had less disintegration time as compared to the Physical mixtures. So, we can conclude that nature , concentration of the superdisintegrant and type of combination of superdisintegrants (Physical mixing vs Co-processing) showed influence on the rate of dissolution. The dissolution rate was found to follow first order kinetics. Keywords: Simvastatin, Crospovidone , Ac-Di-Sol , Fast disintegrating tablets, solvent evaporation method
Authors and Affiliations
Ravi. Srinu, M. Teja Krishna, V. Sai kishore, K. V. S. Prasada Rao
Keywords
Related Articles
- EP ID EP378352
- DOI -
- Views 98
- Downloads 0
A Comprehensive Ethno-pharmacological and Phytochemical Update Review on Medicinal Plant of Terminalia arjuna Roxb. of Bangladesh
This review paper focused on ethno-pharmacological uses and phytochemical constituents of Terminalia arjuna Roxb., an important medicinal plant of Bangladesh, used in various indigenous system of medicine. This review ha...
Formulation and Design of Microparticles based Drug Delivery System of Selective Anti-Retroviral Drug by Chitosan
Abstract:The objective of gift work is to formulate nucleoside reverse transcriptase inhibitor loaded microparticle by counterion elicited aggregation methodology. Chitosan was chosen as polycation and smaller molecular...
Solanum xanthocarpum Chemical Constituents and Medicinal Properties: A Review
India with its knowledge of rich ancient traditional systems of medicine provides a strong base for the utilization of a large number of plants in general healthcare. Large number of herbal drugs existing in India, very...
Comparative Analysis on Nutritional and Antinutritional factors in Raw and Blanched Crotalaria laburnoidesKlotzschleaves from Iramba District, Tanzania
Abstract:This research aimed at investigating the nutritional and antinutritional contents of the leaves of wild edible plant, Crotalaria laburnoides (commonly known as ‘Nsonga’ by natives), in order to provide knowledge...
Age Associated Mitochondrial Stress in Rat Liver, Kidney and Heart: Protective Potential of Docosahexaenoic Acid
Aging is a biological phenomenon concerning all living multicellular organisms. It is degenerative process caused by accumulated damaged lipid and protein that leads to cellular dysfunction, tissue failure, and death. In...