Formulation and Evaluation of Floating Tablet of Pantoprazole Sodium
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2019, Vol 9, Issue 1
Abstract
The Present research work focuses on the formulation and evaluation of Floating tablet of Pantoprazole sodium. Floating tablets were prepared by direct compression method. 40mg of Pantoprazole was taken in a single tablet of 250mg. Floating tablet of pantoprazole sodium increase the gastric residence time as well as bioavailability and thereby showed increased therapeutic efficacy. The addition of gel forming polymer (HPMC) and gas generating agent sodium bicarbonate and citric acid was essential to achieve In vitro buoyancy. Preformulation studies were conducted to select suitable excipient, Combination of different excipient was used to formulate pantoprazole floating tablets. The evaluation parameter such as Weight variation, Thickness, Hardness, Friability, disintegration time, In-vitro drug release studies was conducted. The results were within the limit and were compared with marketed formulation.
Authors and Affiliations
Aiswarya Patnaik, Hara Prasad Patnaik
Keywords
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