The Effect Of Roselle Extract (Hibiscus sabdariffa Linn.) On Blood Glucose Level And Total Antioxidant Level On Diabetic Rat Induced By Streptozotocin
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2014, Vol 4, Issue 10
Abstract
: Roselle (Hibiscus sabdariffa Linn.) contains phenolic compounds, especially anthocyanins which act as antioxidants. The purposes of this study were to examine the antioxidant capacity and capability of purple roselle extract as an antidiabetics in diabetic rats induced by streptozotocin(STZ). A total of 24 male rats was used in this study. The rats were divided into six groups including group of normal rats as standard group (SG), diabetic rats given distilled water (DiW), diabetic rats given roselle extract 72 mg/day/200 g bw (DiR1), diabetic rats given roselle extract 288 mg/day/200 g bw (DiR2), preventive rats (PR1) which were rats given roselle extract 72 mg/day/200 g bw for 11 days then injected with STZ and continued with roselle extract 72 mg/day/200 g bw until the 21th day, and the last group was glibenclamide rats (DiG), were diabetic rats given glibenclamide 0.09 mg/day/200g bw. Roselle extract was given orally administered 2ml/day/rat for 21 days. Results showed that blood sugar of DiR2, DiG and PR1 rat groups tended to decrease. Total antioxidant capacity ( TAC ) in DiR1 (0.2655 ± 0.0016 mM) was same with others group (DiR2, PR1, DiG). Negative control rats (DiW) had the lowest total antioxidant capacity (0.0893 ± 0.0134 mM). The content of malonaldehyde (MDA) of liver not significant (P>0.05) but MDA of kidney was significant (P<0.05), that DiR1, PR1, DiG, DiR2 was lower than in DiW. Insulin content analysis showed that DiR1 had the highest insulin levels (0.4433±0.1802 ng/ml) and differ significantly with DiW. Meanwhile groups of negative control rats (DiW) had the lowest insulin levels (0.1286 ± 0.0337ng/ml). It was concluded that roselle extract had the ability to lower blood sugar (both curative and preventive), increase of antioxidant capacity, and improve insulin production
Authors and Affiliations
Mardiah , Fransiska Rungkat Department of Food Science and Technology, Faculty of Agricultural Engineering, Bogor Agricultural University, Kampus IPB Dar, Endang Prangdimurti, Rizal Damanik
Keywords
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