FORMULATION AND EVALUATION OF FLURBIPROFEN TABLET USING SPHERICAL CRYSTALLIZATION FOR SOLUBILITY ENHANCEMENT
Journal Title: Innoriginal: International Journal Of Sciences - Year 2018, Vol 5, Issue 1
Abstract
Objective : The present study deals with spherical crystallization of Flurbiprofen crystals in order to improve its flow properties, compressibility and enhancement of dissolution characteristics of drug crystals. Methods: Spherical agglomerates of Flurbiprofen prepared by different techniques. Selection of Neutralization technique based on the better percentage yield, drug content, and SEM analysis. Optimization of Flurbiprofen spherical agglomerate was done. Optimized formulation of spherical agglomerate was chosen for preparation of tablet. Response surface methodology using Factorial design was chosen for the optimization of spherical agglomerates. Preparation and evaluation of spherical agglomerate tablet and comparing its dissolution characteristics with conventional as well as marketed product. Results : The micromeritic properties, solubility, In-vitro drug release of spherical agglomerates were evaluated. Spherical agglomeration enhances the micromeritic and dissolution properties of Flurbiprofen. The drug release mechanism from the tablets was found to be case II transport kind of diffusion. Conclusion : It can be concluded that the spherical crystallization technique is an effective approach for the dissolution rate improvement of Flurbiprofen.
Authors and Affiliations
Arun raj R, MEENA KURUP
Keywords
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