FORMULATION AND EVALUATION OF GASTRO-RETENTIVE FLOATING TABLETS
Journal Title: International Journal of Pharmaceutical and Biological Science Archive - Year 2018, Vol 6, Issue 6
Abstract
In case of drugs which are less soluble at alkaline pH of intestine, conventional oral dosage forms having low bioavailability problems due to their rapid gastric transition from stomach. Moreover drugs which show their local action in stomach, get quickly emptied do not get sufficient residence time in stomach. Thus the result is frequency of dose administration in such cases is increased. To solve these problems, numerous efforts have been made to prolong the retention time of drug in stomach. Floating drug delivery system (FDDS) is one of the most significant methods in prolonging the retention time of drug in stomach. FDDS is low-density systems that have enough buoyancy to float over the gastric contents and remain buoyant in the stomach for a prolonged period of time without affecting the gastric emptying rate. The drug is released gradually at the desired rate while the system is floating on the gastric contents which outcomes in an improved control of the fluctuations in plasma drug concentration. This review provides the detailed summary of formulation and evaluation of gastro-retentive floating drug delivery system with their advantages over the conventional drug delivery system and also includes limitation. Key words: Floating Drug Delivery System, Gastro-retentive Drug Delivery System, Gastric Retention, Gastric Residence Time, (GRT) and Plasma drug concentration.
Authors and Affiliations
Priya Gupta
Keywords
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