Formulation and Evaluation of Gastroretentive Floating Microballoons of Norfloxacin
Journal Title: Indo American Journal of Pharmaceutical Research - Year 2011, Vol 1, Issue 5
Abstract
The present study involves preparation and evaluation of floating microballoons with norfloxacin s model drug for prolongation of gastric residence time. The microballoons were prepared by the solvent evaporation method using a combination of polymer Eudragit RS 100 and Eudragit L 100. The shape and surface morphology of prepared microballoons were characterized by optical and scanning electron microscopy, respectively. In vitro drug release studies were performed and drug release kinetics was evaluated using the linear regression method. Effects of stirring rate during preparation, polymer concentration, solvent composition and dissolution medium on the size of microballoons, and drug release were also observed. The prepared microballoons exhibited prolonged drug release (8 hours) and remained buoyant for >10 hours. The mean particle size increased and the drug release rate decreased at higher polymer concentration. No significant effect of the stirring rate during preparation on drug release was observed. In vitro studies demonstrated diffusion-controlled drug release from the microballoons.
Authors and Affiliations
Joydeep Dutta, G. Ganesh Kumar, Vikas Dash, Savendu Saha
Keywords
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