EVALUATION OF PHYSICAL AND CHEMICAL STABILITY OF DOCETAXEL INCORPORATED NANO STRUCTURED LIPID CARRIER SYSTEM
Journal Title: Indo American Journal of Pharmaceutical Research - Year 2017, Vol 7, Issue
Abstract
Abstract Poor physical and chemical stability associated with NLC formulation has been a concern and has taken away the initial attraction in formulating them. Recently it has been reported that the process of lyophilization has been beneficial in improving stability of NLCs (Nanostructured lipid carriers). In the present study Nanostructured lipid carriers of Docetaxel has been formulated using homogenization technique using stearic acid and oleic acid as lipids and soya bean lecithin and poloxamer as surfactant mixture. The optimized lyophilized and non-lyophilized NLCs of Docetaxel formulation was evaluated and compared for its physical stability. From the stability study it can be concluded that process of lyophilization and storage condition significantly influenced the shelf life. The lyophilized product upon storage at 40C, exhibited a long shelf life of 2.73 years. The shelf life of non-lyophilized product and products stored at room temperature was significantly lower. Hence the study concluded that the process of lyophilization significantly improved the stability of the NLC formulations. The stability results revealed that formulations are found to be stable at 40C rather than storage at room temp. Based on this, the study recommended that NLCs should be stored at 40C for the best stability and extended shelf life.
Authors and Affiliations
Vipin K. V*1, Dr. Sarath Chandran C2, Ann Rose Augusthy1
Keywords
Related Articles
- EP ID EP330813
- DOI -
- Views 86
- Downloads 0
COMPREHENSIVE REVIEW OF IMPORTANT ANALYTICAL REAGENTS USED IN SPECTROPHOTOMETRY
Abstract An innovative and comprehensive range of chromogenic reagents or colorimetric reagents are generally used for the application in the field of spectroscopic quantitative and qualitative analysis. There are number...
IMPACT OF PATIENT COUNSELING ON DIABETIC FOOT ULCER PATIENTS
WHO, 1985 Defines diabetic foot ulcer as an Infection, ulceration and/or destruction of deep tissues associated with neurological abnormalities and various degrees of peripheral vascular disease in the lower limb. Aim of...
STABILITY STUDIES OF RIBAVIRIN SYRUP
Ribavirin is an antiviral agent commonly used for the treatment of severe acute respiratory syndrome. The present study investigated the stability of marketed oral Ribavirin syrup. The syrup was subjected to accelerated...
A PERSPECTIVE REVIEW ON HOMALIUM ZEYLANICUM BENTH
Abstract Plant Homalium zeylanicum Benth belongs to Flacourtiaceae family and is distributed in evergreen and semi-evergreen forests, native to south India and srilanka.It is also found in Bangladesh, Laos. Myanmar, Nepa...
FORMULATION AND DEVELOPMENT OF STABLE DOSAGE FORM OF AMLODIPINE BESYALTE AND BENAZEPRIL HYDROCHLORIDE TO OVERCOME PHYSICAL INCOMPATIBILITY
Abstract Amlodipine is a dihydropyridine calcium channel blocker with a slow onset and long duration of action. Benazepril hydrochloride is an angiotensin- converting enzyme inhibitor. But the Amlodipine besylate and Ben...