Formulation and evaluation of Gemcitabine HCl anti-cancer lyophilized powder for injection

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Formulation and evaluation of Gemcitabine HCl anti-cancer lyophilized powder for injection

Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2017, Vol 5, Issue 1

Abstract

Gemcitabine belongs to BCS class III, it has high solubility and low permeability. More over the drug is highly unstable in the liquid formulation. These limitations in the formulation of gemcitabine were addressed in the present investigation. To solve the permeability issue, the drug can be administered through I.V route, because it has good aqueous solubility. The lyophilized from of the drug prevents its deterioration in liquid medium. So the lyophilized drug should be reconstituted with normal saline before administration through I.V route.

Authors and Affiliations

D. Sravanthi, D. Jeevan Mani Babu, B. Nagendra Babu

Keywords

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EP ID EP33423
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