FORMULATION AND EVALUATION OF ISONIAZID AND ETHAMBUTOL HYDROCHLORIDE COMBINATION TABLETS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 2
Abstract
Ethambutol hydrochloride and Isoniazid Drugs are used as Antituberculosis agents. It is mainly used in the initial Treatment of pulmonary tuberculosis. Here in present study compressed tablet of Ethambutol hydrochloride and Isoniazid prepared by using HPMC, HPC, and PVPK -30 as binders. Compressed tablets of Ethambutol hydrochloride and Isoniazid were prepared by wet granulation method. Among different trials of F1 to F9 with wet granulation, the trial F1 showed satisfactory in-vitro drug release profile as compared to that of innovator for formulation. The cumulative percentage of drug release of formulation F1 (Isoniazid) And F1 (Ethambutol) were 99.53 and 99.43 respectively. The result of stability studies of batch F1 indicate that it is stable at 40°C ± 2°C / 75% RH ± 5 % relative humidity as there was no significant differences observe for dissolution and assay after two months.
Authors and Affiliations
Chandira Margret , Jayakar B, Palanisamy P.
Keywords
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