FORMULATION AND EVALUATION OF LOSARTAN POTASSIUM COMPRESSION COATED TABLETS BY OKRA GUM AS A BINDER
Journal Title: International Journal of Pharmaceutical Sciences and Research (IJPSR) - Year 2019, Vol 10, Issue 6
Abstract
The purpose of the present study was to formulate Losartan potassium compression-coated tablets using okra gum as a binder along with synthetic hydrophilic polymers like various grades of Hydroxypropyl methylcellulose (HPMC) and compare the different parameters. The effect of different concentration of okra is to be used in the formulations with varying concentration of the polymers, elucidating the effect of type of polymers and its concentration on release pattern of the drug from the compression-coated tablets. Okra gum was extracted by using acetone. After subsequent evaluation of the gum and the preformulation studies of the drug, fast disintegrating core tablets were prepared. Okra gum was used as binder in varied concentrations (3%, 4% & 5%) and three different grades of Hydroxypropyl methylcellulose (HPMC) were used in 30%, 60% & 90% concentrations to prepare compression coated tablets. Characterization was done, and the drug release pattern was compared among the batches. Preformulation studies like differential scanning calorimeter (DSC), Fourier transform infrared spectroscopy (FTIR) showed that there was no significant interaction between the drug and the polymers. The characterization of the new polymer okra showed that it has swelling properties, and in spite of being a hydrophilic polymer, it can be successfully used in sustained release formulations. Drug release was retarded successfully, which followed zero order reaction, and the best fit model was Korsemeyer Peppas model. This study provides an insight into the usage of okra gum as a rate retardant polymer, which can be successfully used as a binder in compression of tablets.
Authors and Affiliations
R. Mazumder et al.
Keywords
Related Articles
- EP ID EP581473
- DOI 10.13040/IJPSR.0975-8232.10(6).2917-22
- Views 91
- Downloads 0
SYNTHESIS AND ANTIMICROBIAL STUDIES OF NOVEL GLYCOSYL THIOCARBAMIDES
Glycosyl isothiocyanates have been widely used as important intermediates in the synthesis of many biologically active glycosyl derivatives. The glycosyl isothiocyanates have been the focus of synthetic attention during...
ANTIBACTERIAL, ANTIOXIDANT, CYTOTOXICITY AND QUALITATIVE PHYTO-CHEMICAL EVALUATION OF SEED EXTRACTS OF NIGELLA SATIVA AND ITS SILVER NANOPARTICLES
Nigella sativa is considered a miracle herb plant belongs to the Ranunculaceae family, inhabitant to South Asia and South-west Asia. The most important part of the Nigella sativa plant used by human beings are seeds, mos...
EFFECTS OF USING DIFFERENT LEVELS OF CHROMIUM PICOLINATE ON PERFORMANCE, SOME BLOOD BIOCHEMICAL AND INTESTINAL MORPHOLOGY AND MICROFLORA IN ROSS 308 BROILER CHICKS EXPOSED TO THE HEAT STRESS CONDITION
This study was aimed to investigate the effects of different levels of dietary chromium picolinate (CrPic) on performance, some blood biochemical and intestinal morphology and microflora in Ross 308 broiler chicks. A tot...
HISTORY, MANIFESTATION AND PREVENTIVE MEASURES FOR RUBELLA IN INDIA: A REVIEW
Rubella is an eradicable illness on the grounds of immunization against it produces solid protection. The name rubella comes from the Latin language, and it means “little red”. In olden times people thought that rubella...
PHARMACEUTICAL VALIDATION & PROCESS CONCEPTUALISATION OF ANCIENT INDIAN CALCIUM PREPARATION: SHANKHA BHASMA
In the present study, the pharmaceutical and therapeutic dimensions of Shankha Bhasma (Classical Ayurvedic marine medicine) is explored as a substitute for calcium supplements available in the market. Shankha Bhasma was...