FORMULATION AND EVALUATION OF MATRIX TYPE TRANSDERMAL PATCHES OF ATORVASTATIN CALCIUM
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2013, Vol 2, Issue 3
Abstract
In present work was designed to develop suitable transdermal matrix type of Atorvastatin calcium, using Hydroxy propyl methyl cellulose (HPMC) and ethyl cellulose (EC) with PEG 400, n-DB (as plasticizers) and propylene glycol (as penetration enhancer). The solvent casting technique was employed for the preparation of HPMC, and EC film. The dry films were evaluated for weight variation, thickness uniformity, moisture content, moisture uptake, folding endurance and % drug content. In-vitro diffusion studies were performed using cellulose acetate membrane in a Franz’s diffusion cell. The concentration of diffused drug was measured using UV- visible spectrophotometer at λ max 246.2 nm. Patches prepared, from each batch, gave release profile for over 24 hours. Cumulative amount of drug release in 24 hours from all the prepared formulations were found to be in following order: F2 > F3 > F7 > F9 > F8 > F5 > F1 > F6> F4 > F10. Prepared patch from HPMC 5 cps and ethyl cellulose (F2) exhibited good characteristics for sustained release action and other parameters evaluated.
Authors and Affiliations
Asija Rajesh*| Professor & Principal, Maharishi Arvind Institute of Pharmacy, Mansarover, Jaipur, Rajasthan, India-302020., Umesh Kumar| Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020., Asija Sangeeta| Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020., Patel Chirag J| Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020., Mangukia Dhruv| Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020., Patel Pinkesh| Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020.
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