Formulation and evaluation of metoclopramide hydrochloride mouth dissolving tablet
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2014, Vol 2, Issue 4
Abstract
Metoclopromide hydrochloride mouth dissolving tablets preparing were evaluated for pre compression and post compression parameters. The results obtained for angle of repose of the powdered blends was less than 30°, the bulk density was ranged from 0.358to 0.570g/cm, the tapped density was ranged from 0.436 to 0.673g/cm3, the percent compressibility was ranged from 9.31to 26.866%. The mean thickness values were found in the range from 2.57 to 2.77mm, the hardness of formulated tablets was found to be 2.99to3.96Kp. The loss in friability was ranged from 0.16 to 0.48%. The Wetting Time was ranged from 92 ± 1.51 to 99 ± 1.47 seconds, the disintegration Time was ranged from 17.7 to 29.37 seconds. Thus the Disintegrant was suitable in preparing the rapidly disintegrating tablets. The rapid dissolution might be due to fast breakdown of particles of superdisintegrants. In all formulations the drug release was nearer to 100% within 20 minutes. The optimized formulation F7 was selected for accelerated stability studies and the tablets possessed the same parameters even after the stressed conditions, indicates good stability properties of formulation.
Authors and Affiliations
Nagasudha K, Harish Gopinath, Debjit Bhowmik, Nanada Kishore Agarwal, Praveen Khirwadkar
Keywords
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