Formulation and evaluation of mouth dissolving tablets of lamotrigine
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2015, Vol 3, Issue 2
Abstract
Preparation of mouth dissolving tablets of Lamotrigine by direct compression using different concentration of superdisintegrants like Indion 414, sodium starch glycolate (Explotab) and crospovidone (polyphasdone XL).Drug-excipients interaction using FTIR studies. Mouth dissolving tablets of lamotrigine were evaluated for hardness, friability, weight variation, disintegration time, drug content, water absorption ratio, water absorption time. Study in vitro dissolution of lamotrigine from the formulated mouth dissolving tablets. Stability study of formulation as per the ICH guidelines. Results revealed that the tablet of all formulations have acceptable physical parameters .The tablet prepared by direct compression method passes weight variation was found in the range 148 to 152 mg which is below ±7.5%, hardness 3.14 to 3.27 Kg /cm2, percentage friability of 0.28 to 0.48 %, in vitro disintegration time of 17 to 51 sec, drug content uniformity was in between 98.02 to 98.75%, water absorption ratio were found between 38 to 61% and wetting time between 28.12 to 58.23 seconds shows maximum drug release within 5 min.
Authors and Affiliations
Anusha. M, S. Duraivel, DebjitBhowmik, PravinKhirwadkar
Keywords
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