FORMULATION AND EVALUATION OF MUCOADHESIVE TABLETS OF BACLOFEN

Journal Title: International Journal of Pharmacy and Technology - Year 2010, Vol 2, Issue 2

Abstract

The purpose of this research work was to establish mucoadhesive buccal tablets of Baclofen in the forms of monolayered tablets. The tablets were prepared using Sodium methyl cellulose (NaMC ), sodium alginate and Methocel K15M as bioadhesive polymers to impart mucoadhesion. Buccal tablets were evaluated by different parameters such as weight uniformity, content uniformity, thickness, hardness, surface pH, Swelling index, ex vivo mucoadhesive strength, in vitro drug release, and in vitro drug permeation. The present study concludes that mucoadhesive buccal tablets of Baclofen can improve the bio availability of Baclofen.

Authors and Affiliations

B. Gavaskar

Keywords

Related Articles

DEVELOPMENT AND VALIDATION OF UV-SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF PARACETAMOL AND LORNOXICAM IN BULK AND TABLET DOSAGE FORM

A simple and sensitive spectrophotometric method has been developed for simultaneous determination of Paracetamol and Lornoxicam in a binary mixture. In the proposed method, the absorbances were measured at 257.0 nm and...

SPECTROPHOTOMETRIC ESTIMATION OF SPARFLOXACIN IN BULK<br /> AND PHARHARMACEUTICAL DOSAGE FORMS

Two simple and sensitive visible Spectrophotometric methods [I and II] have been developed for the quantitative estimation of Sparfloxacin in bulk and Pharmaceutical dosage forms. Method-I is based on ion-pair complex fo...

OPERATIONAL INDICATORS OF DOTS THERAPY AT MNR MEDICAL COLLEGE &amp; HOSPITAL, SANGAREDDY

Background: The Government of India, WHO and World Bank together reviewed the NTP in the year 1992. The revised strategy was introduced in the country as a Pilot Project since 1993 in a phased manner as Pilot Phase I, Pi...

EMERGING PERSPECTIVES OF RISK AND MEDICATION IN PREGNANCY

Pregnancy is an exciting time in a woman's life. Changes in your body may be matched by changes in your emotions. During pregnancy, some medications are safe and some are not. Some require a higher than usual dose, and s...

ARTHRITIS - A REVIEW OF CLINICAL FEATURES, DIFFERENTIAL DIAGNOSIS<br /> AND TREATMENTS

Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease of unknown etiology affecting both articular tissues and extraarticular organs. The disease is often progressive and results in pain, stiffness, and sw...

Download PDF file
  • EP ID EP155193
  • DOI -
  • Views 131
  • Downloads 0

How To Cite

B. Gavaskar (2010). FORMULATION AND EVALUATION OF MUCOADHESIVE TABLETS OF BACLOFEN. International Journal of Pharmacy and Technology, 2(2), 396-409. https://europub.co.uk/articles/-A-155193