FORMULATION AND EVALUATION OF MUCOADHESIVE TABLETS OF BACLOFEN
Journal Title: International Journal of Pharmacy and Technology - Year 2010, Vol 2, Issue 2
Abstract
The purpose of this research work was to establish mucoadhesive buccal tablets of Baclofen in the forms of monolayered tablets. The tablets were prepared using Sodium methyl cellulose (NaMC ), sodium alginate and Methocel K15M as bioadhesive polymers to impart mucoadhesion. Buccal tablets were evaluated by different parameters such as weight uniformity, content uniformity, thickness, hardness, surface pH, Swelling index, ex vivo mucoadhesive strength, in vitro drug release, and in vitro drug permeation. The present study concludes that mucoadhesive buccal tablets of Baclofen can improve the bio availability of Baclofen.
Authors and Affiliations
B. Gavaskar
Keywords
Related Articles
- EP ID EP155193
- DOI -
- Views 130
- Downloads 0
VALIDATION OF REVERSED - PHASE HPLC METHOD FOR THE ESTIMATION OF CEFIXIME IN CEFIXIME ORAL SUSPENSION.
A simple, fast, precise and accurate, high performance liquid chromatographic method for estimation of Cefixime in Cefixime Oral Suspension was validated using C18 [Hypersil ODS], 4.6x250mm, 5 microns with mobile phase c...
SYNTHESIS, ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES OF NEW BISISATIN MALONOHYDRAZIDES
N1,N3-bis(2-oxoindolin-3-ylidene)malonohydrazides (VIa-i) have been synthesized by the condensation of malonohydrazide (V) with corresponding isatin derivatives (III) in alcohol. The intermediate malonohydrazide (V) was...
TREATEMNET OF CANCER BY MEDICINAL MUSHROOMS
A term combining the words “nutrition” and “pharmaceutical,” is a food or food product that provides health and medical benefits, including the prevention and treatment of diseases. They have shown activities like antiox...
FORMULATION AND EVALUATION OF MUCOADHESIVE TABLETS OF BACLOFEN
The purpose of this research work was to establish mucoadhesive buccal tablets of Baclofen in the forms of monolayered tablets. The tablets were prepared using Sodium methyl cellulose (NaMC ), sodium alginate and Methoce...
FORMULATION OF METFORMIN HYDROCHLORIDE MATRIX TABLETS BY SINTERING TECHNIQUE AND ITS EVALUATION
Metformin hydrochloride is a biguanide, which is used as an oral hypoglycemic agent. It is a white crystalline hygroscopic drug used as an antidiabetic agent specifically for type-2 diabetes mellitus. When given, a divid...