FORMULATION AND EVALUATION OF NASAL IN SITU GEL OF RIZATRIPTAN BENZOATEFORMULATION AND EVALUATION OF NASAL IN SITU GEL OF RIZATRIPTAN BENZOATE
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2017, Vol 6, Issue 2
Abstract
In situ gel drug delivery systems are in elucidation form prior to supervision but once administered, endure gelation in situ, to form a gel. In the current revise nasal in situ gel of rizatriptan Benzoate was primed for the cure of nasal infections to give sustained release of drug and to attain site specific action. Carbopol was use as a pH triggered polymer Different formulations were prepared by varying the concentrations of Carbopo with Hydroxylpropyl Methylcellulose (HPMC). These formulations were evaluated for parameters like drug excipient compatibility, pH, drug content, gelation temperature, viscosity, in vitro drug release, mucoadhesion, ex vivo permeation and stability studies. FTIR study exposed that there was no interface between drug and polymer. pH of all the formulations were initiate to be in the vary of 5.4-6.2 and the drug substance for all the prepared formulations was initiate to be in the assortment of 94%-99%. The results of in vitro drug release and mucoadhesive strength indicated that the optimized formulation F5 and is the most successful formulations of the study, exhibited a sustained drug release of in 87.7% in 7 hours. mucoadhesive strength of 2024.64 and 3267.76 dyne/cm2. From the results it is fulfilled that rizatriptan Benzoate nasal in situ gel produce extended and site specific drug delivery.
Authors and Affiliations
Piyush Agarwal*| Bhupal Nobels College of Pharmaceutical Sciences, Udaipur, Rajasthan, India, Amit Kumar| Dept of Pharmacy, Jodhpur National University, Jodhpur, Rajasthan, India, Y. S. Tanwar| Bhupal Nobels College of Pharmaceutical Sciences, Udaipur, Rajasthan, India, Shailendra Sharma| Jodhpur Institute of Pharmacy, Jodhpur, Rajasthan, India
Keywords
Related Articles
- EP ID EP3833
- DOI -
- Views 428
- Downloads 24
SONOGRAPHIC MEASUREMENTS OF THE SPLEEN IN RELATION TO AGE; A PROSPECTIVE STUDY IN EASTERN NEPALESE ADULTS.
To establish the normal range of the splenic dimensions in East Nepalese adult population ,we used ultasonography to examine 120 subjects ( 60 males and 60 females ),15 each of age group 31-40yrs,41-50yrs,51- 60yrs,61-...
NEURAL MODULATION OF INFLAMMATION
Background: In the present situation of emerging cases of drug allergies, auto-immune disorders and adverse reactions to anti-inflammatory drugs, there is a need to find an alternative for handling abnormal immune statu...
PREVALENCE OF NON-FERMENTING GRAM NEGATIVE BACILLI FROM CLINICAL ISOLATES AND THEIR ANTIBIOGRAM PROFILE
Background and Objectives: Non fermenting gram negative bacilli (NFGNB) are an increasing cause of concern in the hospitals as they produce a therapeutic dilemma for the treating physician.The present study was undertake...
FREQUENCY OF DENGUE FEVER VIRUS AMONG PATIENTS WITH MALARIA-LIKE SYMPTOM IN KHARTOUM STATE.
BACK GROUND: Dengue viral infections are one of the most important mosquito borne diseases in the world. They may be asymptomatic or may give rise to undifferentiated fever, dengue fever, dengue hemorrhagic fever (DHF),...
INVITRO ANTIOXIDANT ACTIVITY AND HPTLC ANALYSIS OF WITHANIA SOMNIFERA
Withania somnifera is a well known medicinal plant having wide range of medicinal properties. HAEWS, MEWS and AEWS were comparatively standardized for the content of Withanolide D by HPTLC. All the samples were screened...