FORMULATION AND EVALUATION OF NOVEL ANTI-BACTERIAL CIPROFLOXACIN LOADED NIOSOMAL CREAM
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2015, Vol 6, Issue 8
Abstract
The development of Ciprofloxacin loaded niosomes using combination of Span-60 and Lipotin A, to increase the local effect of Ciprofloxacin on the bacterial infected skin. Ciprofloxacin encapsulated niosomes were formulated by thin film hydration technique using rotary vacuum evaporator and were incorporated into cream base. The formulation was optimized by changing the ratio of Span 60 and Lipotin A, based on maximum entrapment efficiency and drug retention using ex-vivo drug diffusion study. The selected optimized formulation was subjected to in-vitro study and antibacterial activity study which was compared with the conventional Ciprofloxacin cream. Ciprofloxacin loaded Niosomal cream with 70-90% entrapment efficiency was successfully developed using combination of span60 as non-ionic surfactant and Lipotin A as a dispersing agent. The optimized Ciprofloxacin loaded niosomal cream was found to show maximum drug retention with 71.49% within 12 hours, which has been require for local effect. It also provided more antibacterial activity and sustained release of drug by in-vitro study with 46.22% diffusion within 8 hours, as compared to conventional Ciprofloxacin cream. Thus, the developed Ciprofloxacin loaded niosomal cream was considered to be an enhanced topical delivery of ciprofloxacin through skin with sustained action, with maximum retention for prolong effect and thereby, providing successful local treatment of various bacterial skin infections.
Authors and Affiliations
Vishal Rokade , Pramod Kadu
Keywords
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- EP ID EP122619
- DOI 10.7897/2230-8407.068104
- Views 96
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