FORMULATION AND EVALUATION OF ORAL CONTROLLED FLOATING TABLETS OF ANTI-ASTHAMATIC DRUG
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 1
Abstract
The objective of the present research work is to formulate and evaluate oral controlled floating tablet of anti-asthmatic drug Terbutaline sulphate. The pre and post compression parameters have been studied and the results were found to be within the IP specification. The formulations F3 and F6 showed higher swelling index compared to others. In-vitro release rate studies showed that the maximum drug release was observed in F2 and F9 formulations up to 12 hrs. Optimized formula found to be stable at 45oC and 75% RH for a period of 3 month. FT-IR studies revealed that there was no interaction between drug and the polymers used. From the study it is evident that a promising controlled release floating tablets of Terbutaline sulfate can be developed to increase gastric residence time. Further detailed investigations are required to establish efficacy of these formulations and fix the required dose.
Authors and Affiliations
Sony Yellapu, Debjith Bhowmick, Harish Gopinath, Arvind Gurram, Anusha P
Keywords
Related Articles
- EP ID EP33014
- DOI -
- Views 444
- Downloads 0
Formulation and evaluation of losartan potassium ethosomal gel
Clinically liposomal systems were found to be effective, at forming drug reservoir in the upper layers of the skin for local skin therapy. Recently, it was found that Ethosomal carriers were phospholipid vesicular syst...
Formulation and evaluation of Zolmitriptan controlled release matrix tablets
Controlled release formulations in many case provide significant advantages, including improved therapeutic effect, increased patient compliance by reducing dosing frequency and decrease in incidence and or intensity o...
Formulation and evaluation of Terbutaline sulphate 5mg controlled release tablets for the treatment of nocturnal asthma
The present work was aimed to design & characterize an oral dosage form to release Terbutaline sulphate following a programmed time period (pulsed release system). Pulsatile release tablet comprises a drug containing c...
Study on the effect of different parts of Nyctanthes arbortristis linn. on the hematological parameters of mice
Hematological effect of the ethanolic extracts of the flowers, barks, seeds and leaves of Nyctanthes arbortristis Linn were estimated at the dose levels of 200, 400 and 600 mg/kg body weight (I.P.), which were selected...
Phytochemical profile of three selected plants of Araucaria columnaris, Curcuma longa, Emblica officinalis
A Phytochemical profile of three selected plant species Araucaria columnaris Curcuma longa Emblica officnalis were carried out. Crude dry powder analysis, ash value, solubility, extractive value, fluorescence analysis,...