FORMULATION AND EVALUATION OF ORAL CONTROLLED FLOATING TABLETS OF ANTI-ASTHAMATIC DRUG
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 1
Abstract
The objective of the present research work is to formulate and evaluate oral controlled floating tablet of anti-asthmatic drug Terbutaline sulphate. The pre and post compression parameters have been studied and the results were found to be within the IP specification. The formulations F3 and F6 showed higher swelling index compared to others. In-vitro release rate studies showed that the maximum drug release was observed in F2 and F9 formulations up to 12 hrs. Optimized formula found to be stable at 45oC and 75% RH for a period of 3 month. FT-IR studies revealed that there was no interaction between drug and the polymers used. From the study it is evident that a promising controlled release floating tablets of Terbutaline sulfate can be developed to increase gastric residence time. Further detailed investigations are required to establish efficacy of these formulations and fix the required dose.
Authors and Affiliations
Sony Yellapu, Debjith Bhowmick, Harish Gopinath, Arvind Gurram, Anusha P
Keywords
Related Articles
- EP ID EP33014
- DOI -
- Views 496
- Downloads 0
Formulation and evaluation of fast dissolving Lamivudine oral thin films: an innovation in paediatric medication
The present investigation under taken with objective of formulating Lamivudine fast dissolving oral thin films allowing fast reproducible drug dissolution in oral cavity thus bypassing the first pass metabolism to enha...
Isolation and characterization of bioactive compound from crab Atergatis integerrimus (lamarck) of west coast of Mumbai (India)
The tropical ocean of West Coast of Mumbai is well known for the rich biodiversity of crabs Atergatis integerrimus (Lamarck). The bioactivity of the methanolic extract of these crabs have screen recently and observed t...
Development and validation of RP-HPLC method for stability testing of Roxithromycin and Ambroxol hydrochloride
RP-HPLC method was developed for simultaneous estimation of Roxithromycin and Amroxol hydrochloride in pharmaceutical dosage forms. The method was validated for the simultaneous estimation of Roxithromycin and Ambroxol...
Preclinical evaluation of cardio protective activity of Grewia hirsuta on doxorubicin induced cardiotoxicity in rats
In this study, an attempt was made to investigate preclinical evaluation of cardio protective activity of Grewiahirsuta induced cardio toxicity in rats. The phytochemical screening was done for the selected plant. The...
Development and validation of new RP-HPLC method for simultaneous estimation of drug ceftriaxone and vancomycin in tablet dosage form
A simple, economic, accurate and precise reverse phase high performance liquid chromatography method for analysis of Ceftriaxone and Vancomycin was developed and validated according to ICH guidelines. The quantificatio...