FORMULATION AND EVALUATION OF ORAL DISPERSIBLE TABLET CONTAINING SPIRONOLACTONE HYDROXYPROPYL: β- CYCLODEXTRIN BINARY SYSTEM
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 4
Abstract
Fast dissolving drug delivery system offers a solution for those patients having difficulty in swallowing tablet. In the present study, an attempt has been made to prepare fast dissolving tablets of the drug Spironolactone using superdisintegrants crosspovidone, crosscarmellose sodium and sodium starch glycolate by direct compression technique. The prepared tablets were evaluated for pre and post compression parameters i.e. angle of repose, car’s index, hausner’s ratio, hardness, friability, wetting time, weight variation, in vitro disintegration time and in vitro dissolution study. The hardness of the tablets was in the range of 3.0 ‐ 4.70 Kg/cm². The percentage friability of the tablets was less than one. Weight variation test results showed that the tablets were deviating from the average weight within the permissible limits of ±7.5 %. Drug content uniformity study results showed that uniform dispersion of the drug throughout the formulation i.e. 96.0% to 102.0%. Tablets containing crospovidone showed better disintegrating character along with the rapid release.
Authors and Affiliations
Reeta Thakur , Devender Rathore, Amit Verma
Keywords
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