FORMULATION AND EVALUATION OF ORMELOXIFENE FAST DISSOLVING TABLETS
Journal Title: Asian Journal Of Pharmaceutical Research and Development - Year 2018, Vol 6, Issue 3
Abstract
The objectives of the present work were to enhancedissolution and solubility of slightly water soluble ormeloxifene hydrochloride and formulate fast dissolving tablets. The research work was two-phase process; the first phase was to enhance the solubility and dissolution of ormeloxifene. For this object drugwas processed with different solid dispersion techniques like kneading, co precipitation, melting and solvent evaporation technique with 훽-cyclodextrinand PEG 6000 carrier.The second phase approach was, to formulate as fast dissolving tablet by using the resulted solid dispersion product by direct compression method by using various superdisintagrents.Solid dispersion mixtures were characterized by differential scanning calorimetry, x-ray diffraction studies, and Fourier transform infrared spectroscopy. Thesolubility and dissolutionrate of Ormeloxifene HCl was remarkably increased in the above methods. It was concluded that, Kneading methodhas producebestincrease in solubility and dissolution forOrmeloxifene then other methods.The overall results showed that ormeloxifene fast dissolving tablet formula (F8) using crospovidone,croscarmillose sodium and sodium starch glycolate(combined superdisintegrants) showed shortestdisintegration time, superior drug release profile, high water absorption ratio. In addition the selected formulation had an acceptable hardness and friability and stability,so it was concluded thatcombined superdisintegrant formulawith mannitol diluent was more opt to makeOrmeloxifene fast dissolving tablet
Authors and Affiliations
Abdul Hasan Sathali. A
Keywords
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- EP ID EP498181
- DOI 10.22270/ajprd.v6i3.373
- Views 163
- Downloads 0
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