Formulation and Evaluation of Oro-Dispersible Tablets Using Modified Polysaccharides
Journal Title: Saudi Journal of Medical and Pharmaceutical Sciences - Year 2017, Vol 3, Issue 1
Abstract
Abstract: Orodispersible tablets (ODT) of levocetirizine was prepared using natural polysaccharides ipomoea batatas starch, amorphophalluscampanulatus starch and their modified form by direct compression method and evaluated for their superdisintegrant activity. Levocetirizinedihydrochloride was used as a model drug. The prepared formulations were compared with synthetic superdisintegrants such as crosspovidone and diluent Ludiflash for disintegration and other ODT parameters. FTIR study indicated no interaction between drug and excipients. Precompression parameters, studied for all the formulations were found to be satisfactory. Different concentrations of 2.5%, 5, 7.5% and 10% of modified and unmodified forms of both starches were studied for the improvement in the ODT parameters. The formulations LISN (10%), LISM (10%) (LIS-levocetirizinedihydrochloride+ ipomoea batatas starch; N-Natural; M-Modified) and LASN (10%), LASM (10%) (LAS-levocetirizinedihydrochloride+amorphophalluscampanulatusstarch; N-Natural; M-modified) of both the starches showed better DT than lower concentrations. Synthetic superdisintegrantcrosspovidone was compared with formulations of natural superdisintegrants. The formulation containing crospovidone 5% concentration showed better DT of 32 seconds compared to natural superdisintegrants, and was used for further comparison of modified polysaccharides. The tablets prepared with Ludiflash as diluent without crospovidone, showed no significant difference in disintegration time. The formulation LASMLU (LAS-Levocetirizinedihydrochloride + amorphophalluscampanulatus starch; M-Modified; Lu-Ludiflash) showed 95% of drug release compared to other formulations. The release profile of 10% of modified amorphophalluscampanulatus starch LASM or Ludiflash (LASMLU) formulations did not show any significant difference in release profile. Hence in conclusion starch citrate, a new modified starch at 10% or at 5% concentration with crosspovidone with or without Ludiflash as diluent can be used as superdisintegrant for the preparation of orodispersible tablets. Keywords: Levocetirizine-dihydrochloride, Oro-dispersible tablets, direct compression, ipomoea batatas starch, amorphophalluscampanulatus starch
Authors and Affiliations
P. K. Lakshmi, D. Vinod Kumar, K. Harini
Keywords
Related Articles
- EP ID EP389223
- DOI -
- Views 118
- Downloads 0
Antimicrobial Activity of Spilanthesacmellaand Its Chemical Composition
Abstract:In present study an attempt has been made to study the antimicrobial activity and chemical composition of leaves and flowers of Spilanthesacmella. The leaves and flowers of the plant were collected and subjected...
The Gap between Knowledge and Practices in Standard Endotracheal Suctioning of Intensive Care Unit Nurses in Children’s Hospital Lahore
Abstract: Endotracheal suctioning is a crucial element in the management of the airway in intensive care units. The effectiveness and complication of the endotracheal suctioning procedure is associated with the method of...
Prevalence of Tuberculosis among Livestock Slaughtered for Human Consumption: A Jos Abattoir Based Study
Abstract: Tuberculosis is a zoonotic and infectious granulomatous disease of virtually all vertebrates caused by the bacterial genus, Mycobacterium. Previous studies have shown that both humans and livestock like cattle,...
An Overview on Applications of Guar Gum in Food systems to Modify Structural Properties
Abstract: Polysaccharides define as complex polymers composed of units interlinked with glycosidic bonds originated naturally. Polysaccharides are categorizing in several groups and among them, Gums are those with critic...
Prevalence and Management of Anemia in Moroccan Cancer Patients
Anemia is a common problem in patients with malignancy, particularly if under chemotherapy. Data on prevalence and management of anemia in the Moroccan patients with cancer are non-existing. Therefore, we performed a cro...