Formulation and Evaluation of Oro-Dispersible Tablets Using Modified Polysaccharides

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Formulation and Evaluation of Oro-Dispersible Tablets Using Modified Polysaccharides

Journal Title: Saudi Journal of Medical and Pharmaceutical Sciences - Year 2017, Vol 3, Issue 1

Abstract

Abstract: Orodispersible tablets (ODT) of levocetirizine was prepared using natural polysaccharides ipomoea batatas starch, amorphophalluscampanulatus starch and their modified form by direct compression method and evaluated for their superdisintegrant activity. Levocetirizinedihydrochloride was used as a model drug. The prepared formulations were compared with synthetic superdisintegrants such as crosspovidone and diluent Ludiflash for disintegration and other ODT parameters. FTIR study indicated no interaction between drug and excipients. Precompression parameters, studied for all the formulations were found to be satisfactory. Different concentrations of 2.5%, 5, 7.5% and 10% of modified and unmodified forms of both starches were studied for the improvement in the ODT parameters. The formulations LISN (10%), LISM (10%) (LIS-levocetirizinedihydrochloride+ ipomoea batatas starch; N-Natural; M-Modified) and LASN (10%), LASM (10%) (LAS-levocetirizinedihydrochloride+amorphophalluscampanulatusstarch; N-Natural; M-modified) of both the starches showed better DT than lower concentrations. Synthetic superdisintegrantcrosspovidone was compared with formulations of natural superdisintegrants. The formulation containing crospovidone 5% concentration showed better DT of 32 seconds compared to natural superdisintegrants, and was used for further comparison of modified polysaccharides. The tablets prepared with Ludiflash as diluent without crospovidone, showed no significant difference in disintegration time. The formulation LASMLU (LAS-Levocetirizinedihydrochloride + amorphophalluscampanulatus starch; M-Modified; Lu-Ludiflash) showed 95% of drug release compared to other formulations. The release profile of 10% of modified amorphophalluscampanulatus starch LASM or Ludiflash (LASMLU) formulations did not show any significant difference in release profile. Hence in conclusion starch citrate, a new modified starch at 10% or at 5% concentration with crosspovidone with or without Ludiflash as diluent can be used as superdisintegrant for the preparation of orodispersible tablets. Keywords: Levocetirizine-dihydrochloride, Oro-dispersible tablets, direct compression, ipomoea batatas starch, amorphophalluscampanulatus starch

Authors and Affiliations

P. K. Lakshmi, D. Vinod Kumar, K. Harini

Keywords

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EP ID EP389223
DOI -
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