FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLETS OF DIAZEPAM USING DIFFERENT SUPERDISINTEGRANTS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 3
Abstract
Diazepam orodispersible tablets were prepared to achieve quick onset of action and for maximum bioavailability. The purpose of the present research was to compare the effect of different superdisintegrants on the mouth dissolving property of diazepam tablets. Orodispersible tablets of diazepam were prepared using chitosan, sodium carboxy methyl cellulose, alginic acid, crospovidone and sodium starch glycollate as superdisintegrants by direct compression technique. Prepared tablets were evaluated for weight variation, hardness, friability, content uniformity, wetting time, in vitro dispersion time, in vitro disintegration time and dissolution studies. Disintegration time from all the prepared formulation was found to be in following order: F2<F5<F1<F4<F3. Disintegration time was found to be rapid in F2 formulation. The in vitro dissolution time was found to be 99.91% in 10 minutes for the formulation F2. Crospovidone showed faster disintegration of tablets among all other superdisintegrants.
Authors and Affiliations
Chirag Patel , Rajesh Asija , Dhruv Mangukia , Harish Rathi , Kanu Patel
Keywords
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